Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 81759..82351 Replicon plasmid pPHDD1
Accession NZ_CP065043
Organism Photobacterium damselae subsp. damselae strain AS-16-0963-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IPQ37_RS21015 Protein ID WP_237043387.1
Coordinates 81759..82079 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IPQ37_RS21020 Protein ID WP_013404598.1
Coordinates 82076..82351 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPQ37_RS20995 (IPQ37_20985) 76874..77152 - 279 WP_101731510.1 hypothetical protein -
IPQ37_RS21000 (IPQ37_20990) 78429..79241 + 813 WP_237043385.1 hypothetical protein -
IPQ37_RS21005 (IPQ37_20995) 79975..80538 - 564 WP_237043386.1 hypothetical protein -
IPQ37_RS21010 (IPQ37_21000) 80848..81534 - 687 Protein_76 IS6 family transposase -
IPQ37_RS21015 (IPQ37_21005) 81759..82079 + 321 WP_237043387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IPQ37_RS21020 (IPQ37_21010) 82076..82351 + 276 WP_013404598.1 helix-turn-helix transcriptional regulator Antitoxin
IPQ37_RS21025 (IPQ37_21015) 82613..84085 - 1473 WP_023931202.1 group II intron reverse transcriptase/maturase -
IPQ37_RS21030 (IPQ37_21020) 84932..85822 + 891 WP_237043388.1 site-specific integrase -
IPQ37_RS21035 (IPQ37_21025) 85819..86877 + 1059 WP_237043389.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..176550 176550
- flank IS/Tn - - 84932..85822 890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12064.25 Da        Isoelectric Point: 9.7871

>T182034 WP_237043387.1 NZ_CP065043:81759-82079 [Photobacterium damselae subsp. damselae]
MAWKVDFYSGVEDEILAMPPKIQARIIKLLELIELHGANLGPPHTDSMGDGLFEIRAKAQEGIGRGLFCYLKGQHVYVLR
AFVKKTNKTPKKEIELARERMKEVKL

Download         Length: 321 bp

>T182034 NZ_CP086285:c4547497-4546964 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGAGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGTATTCTATCTTCGTCTGGGGTTTATACAGCTCGTAGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10061.54 Da        Isoelectric Point: 8.9869

>AT182034 WP_013404598.1 NZ_CP065043:82076-82351 [Photobacterium damselae subsp. damselae]
MSLSTLKRKALQNPEVKEAYDDLSVEFELINSLISMREKSGLTQDEVAEKMGTKAPNISRLESGRSNPSLKTLVSYAQAC
GFKLNLGFKHA

Download         Length: 276 bp

>AT182034 NZ_CP086285:c4547774-4547508 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References