Detailed information of TA system TA182032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 446874..447384
• Replicon: chromosome
• Accession: NZ_CP065042
• Organism: Photobacterium damselae subsp. damselae strain AS-16-0963-3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IPQ37_RS16640
• Protein ID: WP_086368444.1
• Coordinates: 447124..447384 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2T3QIT0
• Locus tag: IPQ37_RS16635
• Protein ID: WP_036765838.1
• Coordinates: 446874..447134 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPQ37_RS16625 (IPQ37_16620)	443550..444509	-	960	WP_237043218.1	hypothetical protein	-
IPQ37_RS16630 (IPQ37_16625)	444999..446681	+	1683	WP_151182542.1	RluA family pseudouridine synthase	-
IPQ37_RS16635 (IPQ37_16630)	446874..447134	+	261	WP_036765838.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IPQ37_RS16640 (IPQ37_16635)	447124..447384	+	261	WP_086368444.1	Txe/YoeB family addiction module toxin	Toxin
IPQ37_RS16645 (IPQ37_16640)	447440..447694	-	255	WP_237043219.1	hypothetical protein	-
IPQ37_RS16650 (IPQ37_16645)	447706..448590	-	885	WP_065171313.1	AraC family transcriptional regulator	-
IPQ37_RS16655 (IPQ37_16650)	448750..449898	+	1149	WP_005305892.1	iron-containing alcohol dehydrogenase	-
IPQ37_RS16660 (IPQ37_16655)	450092..451216	+	1125	WP_237043220.1	DNA cytosine methyltransferase	-
IPQ37_RS16665 (IPQ37_16660)	451247..452122	-	876	WP_237043221.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10318.87 Da
• Isoelectric Point: 9.9416

>T182032 WP_086368444.1 NZ_CP065042:447124-447384 [Photobacterium damselae subsp. damselae]
MMINFTPNAWDDYLYWQSQDKKTLKRINKLIENCVRTPFEGIGKPEPLKDNLSGYWSRRIDDTHRLVYKATQNTLVIVAV
RFHYQK

Nucleotide

• Length: 261 bp

>T182032 NZ_CP086285:c3739989-3739672 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCGATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9718.89 Da
• Isoelectric Point: 4.3167

>AT182032 WP_036765838.1 NZ_CP065042:446874-447134 [Photobacterium damselae subsp. damselae]
MTVLSFSEVRGNFKKVCDQVVDDCDAVVIHRRDADNVVLMSESEFNSWKETMYLMSNPVNAANLLESIKQAECGNVQTHE
LLSHDD

Nucleotide

• Length: 261 bp

>AT182032 NZ_CP086285:c3739679-3739392 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A2T3QIT0