Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3541816..3542315 Replicon chromosome
Accession NZ_CP065037
Organism Leifsonia sp. ZF2019

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IT072_RS17420 Protein ID WP_223358094.1
Coordinates 3542055..3542315 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag IT072_RS17415 Protein ID WP_223358093.1
Coordinates 3541816..3542058 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT072_RS17395 (IT072_17305) 3537029..3537379 - 351 WP_223358089.1 metalloregulator ArsR/SmtB family transcription factor -
IT072_RS17400 (IT072_17310) 3537870..3540149 + 2280 WP_223358090.1 Ig-like domain-containing protein -
IT072_RS17405 (IT072_17315) 3540343..3540600 + 258 WP_223358091.1 DUF1049 domain-containing protein -
IT072_RS17410 (IT072_17320) 3540725..3541762 + 1038 WP_223358092.1 L-glyceraldehyde 3-phosphate reductase -
IT072_RS17415 (IT072_17325) 3541816..3542058 + 243 WP_223358093.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IT072_RS17420 (IT072_17330) 3542055..3542315 + 261 WP_223358094.1 Txe/YoeB family addiction module toxin Toxin
IT072_RS17425 (IT072_17335) 3542455..3544017 + 1563 WP_223358095.1 hypothetical protein -
IT072_RS17430 (IT072_17340) 3544044..3545279 + 1236 WP_223358096.1 DUF998 domain-containing protein -
IT072_RS17435 (IT072_17345) 3545307..3546017 + 711 WP_223358097.1 SOS response-associated peptidase -
IT072_RS17440 (IT072_17350) 3546085..3546915 + 831 WP_223358098.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10287.57 Da        Isoelectric Point: 7.3556

>T182017 WP_223358094.1 NZ_CP065037:3542055-3542315 [Leifsonia sp. ZF2019]
VSRELAFDRHGWDDYCYWQTEDRKTLKRINQLIQDVLRDPFTGIGKPEPLKHVLSGAWSRRIDDSNRLVYYVTDSHIVVL
QAREHY

Download         Length: 261 bp

>T182017 NZ_CP086259:c4603761-4603384 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9050.08 Da        Isoelectric Point: 4.8210

>AT182017 WP_223358093.1 NZ_CP065037:3541816-3542058 [Leifsonia sp. ZF2019]
MTATDARKGLFGLIQQVNEDHTSIEVVSKHGNVVIMSKDDYDAMTETAHLLRNAPNAERLLESIERARRGEFEQHDLLDT

Download         Length: 243 bp

>AT182017 NZ_CP086259:c4604185-4603808 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References