Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 190379..190881 | Replicon | chromosome |
| Accession | NZ_CP065036 | ||
| Organism | Pectobacterium parmentieri strain PB20 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A8B3FFY4 |
| Locus tag | PB20LOC_RS00945 | Protein ID | WP_025919527.1 |
| Coordinates | 190379..190633 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A8B3FIJ8 |
| Locus tag | PB20LOC_RS00950 | Protein ID | WP_033070807.1 |
| Coordinates | 190630..190881 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PB20LOC_RS00925 | 185485..186747 | - | 1263 | WP_012822274.1 | L-rhamnose isomerase | - |
| PB20LOC_RS00930 | 186744..188234 | - | 1491 | WP_012822275.1 | rhamnulokinase | - |
| PB20LOC_RS00935 | 188603..189442 | + | 840 | WP_005971146.1 | HTH-type transcriptional activator RhaS | - |
| PB20LOC_RS00940 | 189467..190321 | + | 855 | WP_012822276.1 | helix-turn-helix domain-containing protein | - |
| PB20LOC_RS00945 | 190379..190633 | - | 255 | WP_025919527.1 | Txe/YoeB family addiction module toxin | Toxin |
| PB20LOC_RS00950 | 190630..190881 | - | 252 | WP_033070807.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| PB20LOC_RS00955 | 190956..192644 | - | 1689 | WP_025919529.1 | ABC transporter ATP-binding protein | - |
| PB20LOC_RS00960 | 192641..193507 | - | 867 | WP_012822280.1 | ABC transporter permease | - |
| PB20LOC_RS00965 | 193500..194459 | - | 960 | WP_012822281.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | mgtB / hcp | 107012..249782 | 142770 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10135.66 Da Isoelectric Point: 8.0367
>T182008 WP_025919527.1 NZ_CP065036:c190633-190379 [Pectobacterium parmentieri]
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY
Download Length: 255 bp
>T182008 NZ_CP086259:c2169886-2169779 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9351.64 Da Isoelectric Point: 4.6119
>AT182008 WP_033070807.1 NZ_CP065036:c190881-190630 [Pectobacterium parmentieri]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE
Download Length: 252 bp
>AT182008 NZ_CP086259:2169939-2170000 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B3FFY4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B3FIJ8 |