Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4260964..4261592 Replicon chromosome
Accession NZ_CP065032
Organism Serratia sp. CMO1

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag IT763_RS20250 Protein ID WP_016930174.1
Coordinates 4260964..4261254 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IT763_RS20255 Protein ID WP_016930175.1
Coordinates 4261269..4261592 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT763_RS20240 4257378..4259399 + 2022 WP_033639320.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
IT763_RS20245 4259594..4260733 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
IT763_RS20250 4260964..4261254 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT763_RS20255 4261269..4261592 + 324 WP_016930175.1 HigA family addiction module antidote protein Antitoxin
IT763_RS20260 4261585..4262097 + 513 WP_206194962.1 M48 family metallopeptidase -
IT763_RS20265 4262147..4263127 + 981 WP_143778467.1 Gfo/Idh/MocA family oxidoreductase -
IT763_RS20270 4263129..4263860 + 732 WP_206194963.1 glutamine amidotransferase -
IT763_RS20275 4264116..4265081 + 966 WP_028127587.1 TerC family protein -
IT763_RS20280 4265344..4266579 + 1236 WP_049299890.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T181985 WP_016930174.1 NZ_CP065032:4260964-4261254 [Serratia sp. CMO1]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T181985 NZ_CP086253:3719376-3719684 [Pectobacterium aquaticum]
ATGCAATATAAAGTTTACCGTAATAACGGTAACAGCAACTCATACCCTTACCTGCTCAACATCCAAAGTGACATCATCGG
GGAATTACATACCCGCCTGGTGATACCGTTGTTTCCACTACACAAAATTGCCAGACCACCAGCTCGAAGGCTAACGCCGA
TAGTCACTGTCGAAGGCAACGATTACCTGATAATGACCCATGAAATGGCGAGCGTACGCCGCTCACAACTTGGCAATGAA
GTTATGGATGCGCAGGTGTACCGAAAAACAATCAAGGACGCCGTTGATTTCCTGCTTGATGGGTTCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT181985 WP_016930175.1 NZ_CP065032:4261269-4261592 [Serratia sp. CMO1]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT181985 NZ_CP086253:3719134-3719373 [Pectobacterium aquaticum]
ATGCCCGTAACAAGCGTTCGTCATAAAAAAACGGTCAGTGTGACGCTGGAACCCGTGTTGCTCCAACAGGCACGTGAAGC
CGGAATTAACTTATCCGCAATACTCACCGAGGCGCTGAAGAGAGAAATTCGCCTTTCTGAAGGGGAAAAATGGAAGCAGC
AGAACCAGAAGGCATTACAGGAACTAAACCGTATCACAGATAAACACGGCTTATTATCCGACGATGGCAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References