Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3194494..3195154 Replicon chromosome
Accession NZ_CP065032
Organism Serratia sp. CMO1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IT763_RS15260 Protein ID WP_206194810.1
Coordinates 3194801..3195154 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag IT763_RS15255 Protein ID WP_016927038.1
Coordinates 3194494..3194796 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT763_RS15235 3190099..3191013 - 915 WP_016927041.1 branched-chain amino acid ABC transporter permease -
IT763_RS15240 3191137..3192255 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
IT763_RS15250 3192860..3194068 - 1209 WP_079449935.1 aldose 1-epimerase family protein -
IT763_RS15255 3194494..3194796 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
IT763_RS15260 3194801..3195154 - 354 WP_206194810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT763_RS15265 3195593..3196888 + 1296 WP_206194811.1 MFS transporter -
IT763_RS15270 3196916..3197722 + 807 WP_048796852.1 substrate-binding domain-containing protein -
IT763_RS15275 3197697..3198596 - 900 WP_206194812.1 LysR family transcriptional regulator -
IT763_RS15280 3198701..3199066 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13461.35 Da        Isoelectric Point: 8.4832

>T181981 WP_206194810.1 NZ_CP065032:c3195154-3194801 [Serratia sp. CMO1]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNERRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T181981 NZ_CP086253:c2943808-2943530 [Pectobacterium aquaticum]
ATGAAAAAGCAAAGGGAAATTGCATATTCTGGTCAATTCCAACGTGATGTGAAAAAAGCGCAACGGCGACATAAAAACAT
GAACAAGCTTAAAACGCTTATGCAGCTTTTGCTTGAAGACAAACGACCGTTGCCACAGGAATATCAGGATCACCCCCTCC
AGGGAAACTATAAAGGCTACAGAGATGCGCATATCGAGCCGGATTGGCTTCTTATTTACAAGCTGACCGATGACGTTTTG
CGTTTTGAACGTACAGGGACGCACGCTGACCTTTTCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT181981 WP_016927038.1 NZ_CP065032:c3194796-3194494 [Serratia sp. CMO1]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT181981 NZ_CP086253:c2944072-2943812 [Pectobacterium aquaticum]
ATGGCAGCGAATGCATTTGTACGTGCCCGTATTGATGAGAATCTTAAAAATGAAGCAGCGGAAGTGTTGGCTAGCATGGG
GTTGACGGTATCGGATCTGGTGCGCATAACGTTAACGAAAGTGGCTAAAGAAAAAGCACTTCCATTTGATATGCATGTCC
CTAATAAGCTTACCGCACAAACGATGGCTGACAGCGAGAAAGGGGTTGATGTCTATACAGCAAAAGACGCCGCCGATCTG
TTTGATAAATTAGGGATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References