Detailed information of TA system TA181967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 4897382..4898733
• Replicon: chromosome
• Accession: NZ_CP065031
• Organism: Pectobacterium brasiliense strain F126

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: F126LOC_RS21570
• Protein ID: WP_119871557.1
• Coordinates: 4897693..4898733 (+)
• Length: 347 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A086EBR8
• Locus tag: F126LOC_RS21565
• Protein ID: WP_039279922.1
• Coordinates: 4897382..4897696 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F126LOC_RS21540	4893179..4894213	+	1035	WP_119871561.1	putative FMN-dependent luciferase-like monooxygenase	-
F126LOC_RS21545	4894210..4895343	+	1134	WP_119871560.1	alkylhydroperoxidase domain protein	-
F126LOC_RS21550	4895400..4895912	-	513	WP_185893742.1	phenolic acid decarboxylase	-
F126LOC_RS21555	4896012..4896884	+	873	WP_119871558.1	LysR family transcriptional regulator	-
F126LOC_RS21560	4897071..4897397	+	327	WP_039510297.1	helix-turn-helix domain-containing protein	-
F126LOC_RS21565	4897382..4897696	+	315	WP_039279922.1	HipA N-terminal domain-containing protein	Antitoxin
F126LOC_RS21570	4897693..4898733	+	1041	WP_119871557.1	HipA domain-containing protein	Toxin
F126LOC_RS21575	4898793..4899416	-	624	WP_119871556.1	LysE family translocator	-
F126LOC_RS21580	4899684..4900439	+	756	WP_119871555.1	thiol:disulfide interchange protein DsbG	-
F126LOC_RS21585	4900473..4901378	-	906	WP_119871554.1	siderophore-interacting protein	-
F126LOC_RS21590	4901633..4901884	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
F126LOC_RS21595	4901881..4902168	+	288	WP_015842269.1	type II toxin-antitoxin system RelE/ParE family toxin	-
F126LOC_RS21600	4902286..4903638	-	1353	WP_119871553.1	glutathione-disulfide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (57-307)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 347 a.a.
• Molecular weight: 39677.65 Da
• Isoelectric Point: 6.4479

>T181967 WP_119871557.1 NZ_CP065031:4897693-4898733 [Pectobacterium brasiliense]
MTRCRILLTPLTHEEEIATGYSRKGLKHLAGKMHTSPDLRFTRQQFMHDLPQAQKGMSISGYQPKIQLVLEEQAFTVVDH
QGLYILKHSPIEFPYLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKTHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLMHLRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADLTKEAECVETTYRDSFMP
ADAIETTLRCYRHRLNLMSILDAERI

Nucleotide

• Length: 1041 bp

>T181967 NZ_CP086229:c2425250-2424882 [Streptomyces clavuligerus]
ATGCACTACCTCACCCTGCCCGAGCTGCTGAACCTCGCGGAGCGGCTGCGGGCGGCCGAGGTGCGCGACTACGGTCTGCT
GGACTCCGCCCTCGCGCGCCCCCAGGCGAGCGTCTTCGGCCAGGACGCCTACCCGGATGTCTGGCAGAAGGCCGCCGCCC
TGATGGAGTCCCTGGCCCGCAACCACGGACTGGTCGACGGCAACAAGCGGATCGCCTGGTATGCCACCTGGGTCTTTCTC
CATGTGAACGGCCATCCGCTGGACCCGGAATTCGACGTGGACGAGGCGGAACGGTTTGTTCTGGACGTCTGCCAGGGGGC
ACTCGACGTCCCCAAGATCGCGTCGGGGCTGCTGCGCTTCGCCCGCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11898.74 Da
• Isoelectric Point: 9.8041

>AT181967 WP_039279922.1 NZ_CP065031:4897382-4897696 [Pectobacterium brasiliense]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSRTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA

Nucleotide

• Length: 315 bp

>AT181967 NZ_CP086229:c2425447-2425250 [Streptomyces clavuligerus]
ATGGCTGGTCTCAATGTGCGATTCACCGAGGAAGAGCTCACCGCCCTGCGGGAGCGGGCCGAAGCGGAGGGCCGCAGTAT
GCAGTCCTTCGCGCACGACGCGGTGATCAGAGCGATCAACGAACGCGCGCGGCTGTTCAACGAGGCCGCCGAGCATGTGC
TGAGGGCGAGCGAGGAGCTGAACCGGAGGCTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A086EBR8