Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 398277..399001 Replicon chromosome
Accession NZ_CP065030
Organism Pectobacterium versatile strain F131

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F131LOC_RS01770 Protein ID WP_103971372.1
Coordinates 398277..398588 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F131LOC_RS01775 Protein ID WP_103861592.1
Coordinates 398585..399001 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F131LOC_RS01740 393290..393937 + 648 WP_010308671.1 type I-E CRISPR-associated protein Cse2/CasB -
F131LOC_RS01745 393941..395008 + 1068 WP_103971369.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
F131LOC_RS01750 395018..395752 + 735 WP_103971370.1 type I-E CRISPR-associated protein Cas5/CasD -
F131LOC_RS01755 395752..396399 + 648 WP_095701367.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -
F131LOC_RS01760 396427..397344 + 918 WP_010308688.1 type I-E CRISPR-associated endonuclease Cas1 -
F131LOC_RS01765 397345..397638 + 294 WP_103971371.1 type I-E CRISPR-associated endoribonuclease Cas2 -
F131LOC_RS01770 398277..398588 + 312 WP_103971372.1 type II toxin-antitoxin system HigB family toxin Toxin
F131LOC_RS01775 398585..399001 + 417 WP_103861592.1 helix-turn-helix domain-containing protein Antitoxin
F131LOC_RS01780 399208..399711 - 504 WP_103861591.1 hypothetical protein -
F131LOC_RS01785 400058..400294 + 237 WP_103971373.1 type I-E CRISPR-associated endoribonuclease Cas2 -
F131LOC_RS01790 401200..401658 + 459 WP_010286715.1 hypothetical protein -
F131LOC_RS01795 401756..403108 - 1353 WP_103971374.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12460.33 Da        Isoelectric Point: 9.8530

>T181939 WP_103971372.1 NZ_CP065030:398277-398588 [Pectobacterium versatile]
MHVIPRAPFDTATTQFPNQAAALDDLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE

Download         Length: 312 bp

>T181939 NZ_CP086215:2771097-2771306 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15405.70 Da        Isoelectric Point: 4.8037

>AT181939 WP_103861592.1 NZ_CP065030:398585-399001 [Pectobacterium versatile]
MMYADAIKAANNLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILKGERTLTLDHMRALAKRFNIPVSAFVD

Download         Length: 417 bp

>AT181939 NZ_CP086215:2770792-2771085 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References