181931

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 790921..791853 Replicon plasmid pSymB
Accession NZ_CP065022
Organism Sinorhizobium meliloti strain S35m

Toxin (Protein)


Gene name - Uniprot ID Q92VJ4
Locus tag I0J99_RS28140 Protein ID WP_010975576.1
Coordinates 791299..791853 (+) Length 185 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID H0G7T7
Locus tag I0J99_RS28135 Protein ID WP_003534594.1
Coordinates 790921..791292 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0J99_RS28115 786808..787191 + 384 WP_014530516.1 RidA family protein -
I0J99_RS28120 787208..789196 + 1989 WP_088202704.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
I0J99_RS28125 789193..790062 + 870 WP_014527288.1 hydroxymethylglutaryl-CoA lyase -
I0J99_RS28130 790059..790844 + 786 WP_017264723.1 crotonase/enoyl-CoA hydratase family protein -
I0J99_RS28135 790921..791292 + 372 WP_003534594.1 DUF2384 domain-containing protein Antitoxin
I0J99_RS28140 791299..791853 + 555 WP_010975576.1 RES family NAD+ phosphorylase Toxin
I0J99_RS28145 791989..793359 - 1371 WP_015008367.1 FAD-binding oxidoreductase -
I0J99_RS28150 793471..794577 - 1107 WP_013850797.1 sulfate/molybdate ABC transporter ATP-binding protein -
I0J99_RS28155 794593..795468 - 876 WP_013850796.1 sulfate ABC transporter permease subunit CysW -
I0J99_RS28160 795458..796324 - 867 WP_015008365.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1716787 1716787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(23-177)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20459.35 Da        Isoelectric Point: 6.4901

>T181931 WP_010975576.1 NZ_CP065022:791299-791853 [Sinorhizobium meliloti]
MRKHIPPASRPDPEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV

Download         Length: 555 bp

>T181931 NZ_CP086215:18809-18985 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13113.26 Da        Isoelectric Point: 9.9996

>AT181931 WP_003534594.1 NZ_CP065022:790921-791292 [Sinorhizobium meliloti]
MMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Download         Length: 372 bp

>AT181931 NZ_CP086215:c19147-18973 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92VJ4

Antitoxin

Source ID Structure
AlphaFold DB H0G7T7

References