Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 428193..428860 Replicon plasmid pSymB
Accession NZ_CP065022
Organism Sinorhizobium meliloti strain S35m

Toxin (Protein)


Gene name vapC Uniprot ID A0A7X2CQG3
Locus tag I0J99_RS26465 Protein ID WP_014527488.1
Coordinates 428193..428636 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag I0J99_RS26470 Protein ID WP_010975287.1
Coordinates 428633..428860 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0J99_RS26445 423650..425842 + 2193 WP_017264375.1 hydantoinase B/oxoprolinase family protein -
I0J99_RS26450 425846..426343 + 498 WP_010975282.1 acetone carboxylase subunit gamma -
I0J99_RS26455 426340..427170 + 831 WP_014527489.1 SDR family oxidoreductase -
I0J99_RS26460 427239..428177 + 939 WP_017264373.1 choline ABC transporter substrate-binding protein -
I0J99_RS26465 428193..428636 - 444 WP_014527488.1 PIN domain-containing protein Toxin
I0J99_RS26470 428633..428860 - 228 WP_010975287.1 hypothetical protein Antitoxin
I0J99_RS26475 429044..429517 - 474 WP_017264371.1 DUF2269 family protein -
I0J99_RS26480 429517..430806 - 1290 WP_014527486.1 SDR family oxidoreductase -
I0J99_RS26485 431175..432467 + 1293 WP_127632676.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
I0J99_RS26490 432585..433466 + 882 WP_010975291.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1716787 1716787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15592.86 Da        Isoelectric Point: 6.6378

>T181930 WP_014527488.1 NZ_CP065022:c428636-428193 [Sinorhizobium meliloti]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPAMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T181930 NZ_CP086213:c6155421-6155143 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT181930 WP_010975287.1 NZ_CP065022:c428860-428633 [Sinorhizobium meliloti]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT181930 NZ_CP086213:c6155131-6154826 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2CQG3

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References