Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 428193..428860 | Replicon | plasmid pSymB |
Accession | NZ_CP065022 | ||
Organism | Sinorhizobium meliloti strain S35m |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A7X2CQG3 |
Locus tag | I0J99_RS26465 | Protein ID | WP_014527488.1 |
Coordinates | 428193..428636 (-) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q92WE1 |
Locus tag | I0J99_RS26470 | Protein ID | WP_010975287.1 |
Coordinates | 428633..428860 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I0J99_RS26445 | 423650..425842 | + | 2193 | WP_017264375.1 | hydantoinase B/oxoprolinase family protein | - |
I0J99_RS26450 | 425846..426343 | + | 498 | WP_010975282.1 | acetone carboxylase subunit gamma | - |
I0J99_RS26455 | 426340..427170 | + | 831 | WP_014527489.1 | SDR family oxidoreductase | - |
I0J99_RS26460 | 427239..428177 | + | 939 | WP_017264373.1 | choline ABC transporter substrate-binding protein | - |
I0J99_RS26465 | 428193..428636 | - | 444 | WP_014527488.1 | PIN domain-containing protein | Toxin |
I0J99_RS26470 | 428633..428860 | - | 228 | WP_010975287.1 | hypothetical protein | Antitoxin |
I0J99_RS26475 | 429044..429517 | - | 474 | WP_017264371.1 | DUF2269 family protein | - |
I0J99_RS26480 | 429517..430806 | - | 1290 | WP_014527486.1 | SDR family oxidoreductase | - |
I0J99_RS26485 | 431175..432467 | + | 1293 | WP_127632676.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
I0J99_RS26490 | 432585..433466 | + | 882 | WP_010975291.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Mobilizable plasmid | - | htpB | 1..1716787 | 1716787 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 15592.86 Da Isoelectric Point: 6.6378
>T181930 WP_014527488.1 NZ_CP065022:c428636-428193 [Sinorhizobium meliloti]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPAMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPAMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS
Download Length: 444 bp
>T181930 NZ_CP086213:c6155421-6155143 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8174.39 Da Isoelectric Point: 9.1096
>AT181930 WP_010975287.1 NZ_CP065022:c428860-428633 [Sinorhizobium meliloti]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA
Download Length: 228 bp
>AT181930 NZ_CP086213:c6155131-6154826 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7X2CQG3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q92WE1 |