Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 74191..74725 Replicon plasmid pSymB
Accession NZ_CP065022
Organism Sinorhizobium meliloti strain S35m

Toxin (Protein)


Gene name parE Uniprot ID Q92X99
Locus tag I0J99_RS24780 Protein ID WP_010974986.1
Coordinates 74429..74725 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag I0J99_RS24775 Protein ID WP_003527850.1
Coordinates 74191..74439 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0J99_RS24745 69377..70420 + 1044 WP_010974980.1 iron ABC transporter permease -
I0J99_RS24750 70417..71217 + 801 WP_010974981.1 ABC transporter ATP-binding protein -
I0J99_RS24755 71221..72000 + 780 WP_010974982.1 methyltransferase domain-containing protein -
I0J99_RS24760 72092..73288 + 1197 WP_206379515.1 IS256 family transposase -
I0J99_RS24765 73447..73572 - 126 Protein_62 IS481 family transposase -
I0J99_RS24770 73928..74083 + 156 WP_127633776.1 hypothetical protein -
I0J99_RS24775 74191..74439 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
I0J99_RS24780 74429..74725 + 297 WP_010974986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I0J99_RS24785 74806..75066 - 261 Protein_66 helix-turn-helix domain containing protein -
I0J99_RS24790 75645..76043 + 399 WP_010974988.1 hypothetical protein -
I0J99_RS24795 76210..76395 + 186 WP_010974989.1 hypothetical protein -
I0J99_RS24800 76399..76845 - 447 WP_041170054.1 DNA-binding protein -
I0J99_RS24805 77135..77344 + 210 WP_003527838.1 dodecin family protein -
I0J99_RS24810 77877..79280 + 1404 WP_010974991.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1716787 1716787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-91)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 10.6593

>T181929 WP_010974986.1 NZ_CP065022:74429-74725 [Sinorhizobium meliloti]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAVGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRVDAQRHL

Download         Length: 297 bp

>T181929 NZ_CP086213:c5772045-5771863 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT181929 WP_003527850.1 NZ_CP065022:74191-74439 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT181929 NZ_CP086213:c5771835-5771431 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92X99

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References