Detailed information of TA system TA181887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3340065..3340578
• Replicon: chromosome
• Accession: NZ_CP064923
• Organism: Acaryochloris marina S15

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I1H34_RS15560
• Protein ID: WP_235108831.1
• Coordinates: 3340345..3340578 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I1H34_RS15555
• Protein ID: WP_212661944.1
• Coordinates: 3340065..3340355 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1H34_RS15540 (I1H34_15525)	3335510..3336262	+	753	WP_212661941.1	ABC transporter ATP-binding protein	-
I1H34_RS15545 (I1H34_15530)	3336259..3338865	+	2607	WP_212661942.1	ABC transporter permease	-
I1H34_RS15550 (I1H34_15535)	3338868..3339989	+	1122	WP_212661943.1	lipocalin-like domain-containing protein	-
I1H34_RS15555 (I1H34_15540)	3340065..3340355	-	291	WP_212661944.1	helix-turn-helix transcriptional regulator	Antitoxin
I1H34_RS15560 (I1H34_15545)	3340345..3340578	-	234	WP_235108831.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I1H34_RS15565 (I1H34_15550)	3340759..3341712	-	954	WP_249369283.1	hypothetical protein	-
I1H34_RS15570 (I1H34_15555)	3341782..3344121	-	2340	WP_212661947.1	single-stranded-DNA-specific exonuclease RecJ	-
I1H34_RS15575 (I1H34_15560)	3344111..3344275	-	165	WP_212661948.1	hypothetical protein	-
I1H34_RS15580 (I1H34_15565)	3344466..3345236	-	771	WP_249369286.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (3-70)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-89)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8993.72 Da
• Isoelectric Point: 10.8920

>T181887 WP_235108831.1 NZ_CP064923:c3340578-3340345 [Acaryochloris marina S15]
MLEFGPNLGMPHTRSMGDRLFELRVKSKEGIARVFYCTLVGEKIVMLHSFVKKTQKTPKQELQIARRRLKEVLKHDP

Nucleotide

• Length: 234 bp

>T181887 NZ_CP086197:1486607-1486858 [Xanthomonas oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10649.23 Da
• Isoelectric Point: 7.1666

>AT181887 WP_212661944.1 NZ_CP064923:c3340355-3340065 [Acaryochloris marina S15]
MTHEELKAKALEQLEVAEEYNKLEEEFSLLRQMLAARQQAGMTQADIAQKMGTKATAVTRLESSLSSGKHSPSLSTLRKY
AKAVGCRLEVTLIPEQ

Nucleotide

• Length: 291 bp

>AT181887 NZ_CP086197:1486302-1486580 [Xanthomonas oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA