Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2346369..2346972 Replicon chromosome
Accession NZ_CP064923
Organism Acaryochloris marina S15

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag I1H34_RS11350 Protein ID WP_212665715.1
Coordinates 2346688..2346972 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I1H34_RS11345 Protein ID WP_212665714.1
Coordinates 2346369..2346680 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1H34_RS11315 (I1H34_11310) 2341496..2342251 + 756 WP_212665708.1 TIGR04283 family arsenosugar biosynthesis glycosyltransferase -
I1H34_RS11320 (I1H34_11315) 2342248..2343504 - 1257 WP_212665709.1 methionine adenosyltransferase -
I1H34_RS11325 (I1H34_11320) 2343646..2344386 - 741 WP_212665710.1 HAD family hydrolase -
I1H34_RS11330 (I1H34_11325) 2344588..2345220 + 633 WP_212665711.1 class I SAM-dependent methyltransferase -
I1H34_RS11335 (I1H34_11330) 2345223..2345828 - 606 WP_212665712.1 class I SAM-dependent methyltransferase -
I1H34_RS11340 (I1H34_11335) 2345917..2346303 + 387 WP_212665713.1 hypothetical protein -
I1H34_RS11345 (I1H34_11340) 2346369..2346680 - 312 WP_212665714.1 HigA family addiction module antitoxin Antitoxin
I1H34_RS11350 (I1H34_11345) 2346688..2346972 - 285 WP_212665715.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I1H34_RS11355 (I1H34_11350) 2347098..2347418 - 321 WP_212665716.1 hypothetical protein -
I1H34_RS11360 (I1H34_11355) 2347452..2347877 - 426 WP_212665717.1 GNAT family N-acetyltransferase -
I1H34_RS11365 (I1H34_11360) 2347956..2349707 - 1752 WP_212665718.1 ABC transporter ATP-binding protein/permease -
I1H34_RS11370 (I1H34_11365) 2349793..2350674 + 882 WP_212665719.1 inositol monophosphatase family protein -
I1H34_RS11375 (I1H34_11370) 2350663..2351790 - 1128 WP_212665720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-96)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10836.39 Da        Isoelectric Point: 8.0000

>T181884 WP_212665715.1 NZ_CP064923:c2346972-2346688 [Acaryochloris marina S15]
MIVGFSSKETKLIFDGSTSRVYPPDIQKIALRKLLILDAATSVNDLRIPPGNRLEKLVRDRQGQYSIRINSQWRICFTWT
AENDADQVEIVDYH

Download         Length: 285 bp

>T181884 NZ_CP086196:3183881-3184015 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11779.39 Da        Isoelectric Point: 6.7232

>AT181884 WP_212665714.1 NZ_CP064923:c2346680-2346369 [Acaryochloris marina S15]
MENGRLPIIHPGEILKLEFLEPLDLTPYRLSKDIGVAQTRISEILSGKRSITADTALRLSQYFGNSAQFWLNLQTQYDLR
QAQETNRDVYSHIPTVQLTHLPS

Download         Length: 312 bp

>AT181884 NZ_CP086196:3183665-3183817 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References