Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 723165..723786 Replicon chromosome
Accession NZ_CP064879
Organism Tolypothrix sp. PCC 7601

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HG267_RS02930 Protein ID WP_045872112.1
Coordinates 723165..723458 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HG267_RS02935 Protein ID WP_045871837.1
Coordinates 723472..723786 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG267_RS02900 (HG267_02900) 718185..718370 + 186 WP_071989436.1 hypothetical protein -
HG267_RS02905 (HG267_02910) 718741..719253 + 513 WP_045871833.1 inorganic diphosphatase -
HG267_RS02910 (HG267_02915) 719504..719887 + 384 WP_045872111.1 aspartate 1-decarboxylase -
HG267_RS02915 (HG267_02920) 719900..720802 + 903 WP_045871834.1 MBL fold metallo-hydrolase -
HG267_RS02920 (HG267_02925) 720940..722010 - 1071 WP_045871835.1 anthranilate phosphoribosyltransferase family protein -
HG267_RS02925 (HG267_02930) 722092..723039 - 948 WP_045871836.1 LysR family transcriptional regulator -
HG267_RS02930 (HG267_02935) 723165..723458 + 294 WP_045872112.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HG267_RS02935 (HG267_02940) 723472..723786 + 315 WP_045871837.1 HigA family addiction module antitoxin Antitoxin
HG267_RS02940 (HG267_02945) 724384..725136 + 753 WP_045871838.1 pentapeptide repeat-containing protein -
HG267_RS02945 (HG267_02950) 725262..726566 - 1305 WP_194007890.1 HEAT repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11110.59 Da        Isoelectric Point: 6.4511

>T181871 WP_045872112.1 NZ_CP064879:723165-723458 [Tolypothrix sp. PCC 7601]
MIVSFKNKATEDIFDGNDSKEARKQCPINCWGVAQRKLDQLNAAFSLDDMKVPPGNRLEALKGDRKGQHSIRINDQYRIC
FTWIPEGVSEVEIVDYH

Download         Length: 294 bp

>T181871 NZ_CP086194:3956305-3956634 [Xanthomonas oryzae]
TTGCATCATGTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTC
CGATTTATCTGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCA
AGTTCGAGCGCTATCAGGCCGAGGCCCTGATTCACCGACACTTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACG
GATGGTTTGAAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGATTGGTA
TTTCCGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12030.75 Da        Isoelectric Point: 7.4026

>AT181871 WP_045871837.1 NZ_CP064879:723472-723786 [Tolypothrix sp. PCC 7601]
MRVPKHRSPSHPGEILLKDFLEEMGISQRELADAIHVPYQRINEIVNQKRGITPSTALRLAKFFGNSSEFWLNLQQNWEL
YHVLLAEEAELKNIKQFKSSEATA

Download         Length: 315 bp

>AT181871 NZ_CP086194:3956631-3957050 [Xanthomonas oryzae]
ATGATCACGTTTACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACTGGGCCGAGGTGCGCCCACTGATCGAAG
AAGTACTAGGGAACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References