Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3574267..3574941 Replicon chromosome
Accession NZ_CP064829
Organism Morganella morganii subsp. morganii strain 621164

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IZ188_RS17050 Protein ID WP_143970176.1
Coordinates 3574267..3574590 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IZ188_RS17055 Protein ID WP_143970175.1
Coordinates 3574636..3574941 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ188_RS17030 (IZ188_17025) 3569695..3570957 - 1263 WP_004237101.1 multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR -
IZ188_RS17035 (IZ188_17030) 3570970..3572358 - 1389 WP_214182340.1 DNA repair protein RadA -
IZ188_RS17040 (IZ188_17035) 3572384..3573361 - 978 WP_004242106.1 phosphoserine phosphatase -
IZ188_RS17045 (IZ188_17040) 3573463..3574122 + 660 WP_214182339.1 YtjB family periplasmic protein -
IZ188_RS17050 (IZ188_17045) 3574267..3574590 + 324 WP_143970176.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IZ188_RS17055 (IZ188_17050) 3574636..3574941 + 306 WP_143970175.1 NadS family protein Antitoxin
IZ188_RS17060 (IZ188_17055) 3574993..3575376 - 384 WP_004237097.1 fluoride efflux transporter CrcB -
IZ188_RS17065 (IZ188_17060) 3575417..3576499 - 1083 WP_214182338.1 FUSC family protein -
IZ188_RS17070 (IZ188_17065) 3576512..3577678 - 1167 WP_032099034.1 NAD-binding protein -
IZ188_RS17075 (IZ188_17070) 3577691..3578683 - 993 WP_004237091.1 urea transporter -
IZ188_RS17080 (IZ188_17075) 3578777..3579742 - 966 WP_015422437.1 urease accessory protein UreD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(9-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-87)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12658.48 Da        Isoelectric Point: 9.8617

>T181800 WP_143970176.1 NZ_CP064829:3574267-3574590 [Morganella morganii subsp. morganii]
MDYLEFIETKIFSHTRKEMMTDDEFREFQSYLLENYERGNTISQTGGCKKIRWQRRGTGKQGGLRVIYHALPAHGRLYLL
LIYPKNVKDDLSSQERTVLRSLSQKLN

Download         Length: 324 bp

>T181800 NZ_CP086174:4033786-4034196 [Streptomyces fungicidicus]
GTGATCTACCTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCGAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCCGGGGCCATCGCATCCTGCTACGTGCAACGCGCCGAGTTCCTCCACAGTGCCCGGAACGGGCGCGAGTACGACG
AGATCACGGAAATGTTCACCGACCTCTACCCCGACGTGTCGGTACCGAAGAACGCGGGGCGCTGGATCGGCGCGGTGCAG
CACCGCATGGCTCGGGCAGGGGAGCATCGCAGCGCCTCGGCGGTGGACCTCCTCATCGCCGCCACCGCGGCCCACCATGG
CCTGGCTGTCCTCCACGATGATGCCGACTATCGGGCGATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACATCGCTTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11462.43 Da        Isoelectric Point: 9.8337

>AT181800 WP_143970175.1 NZ_CP064829:3574636-3574941 [Morganella morganii subsp. morganii]
MDKTLFENLVSSMEEMVAIEKGHVVPAQENRHRHPIPDVKAIRKHAGLKQAEFADAIGSSVDLVRSWEQHRRIPSGIALK
MLYLIEKQPALLCTLRSIPLR

Download         Length: 306 bp

>AT181800 NZ_CP086174:4033568-4033789 [Streptomyces fungicidicus]
ATGTCCGTGACTCAGATTGACATCGACGACGACGCCCTGGAGCGAGCCATGGCTCTGGCCCACGTCCGGACCAAGAAGGA
GGCGGTCAACCTCGCTCTGAATTTCTATGCCGAGCAGCAGGAGCGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GTGAGTGGGGTGCCGTTGAGGACGCCGAGCGTCTGCACAGGGCGGAGAAGCGCAACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References