Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2405701..2406359 Replicon chromosome
Accession NZ_CP064828
Organism Morganella morganii subsp. morganii strain ZJC25

Toxin (Protein)


Gene name higB Uniprot ID A0A447J593
Locus tag IZ183_RS11845 Protein ID WP_032098584.1
Coordinates 2406006..2406359 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TDD0
Locus tag IZ183_RS11840 Protein ID WP_004236876.1
Coordinates 2405701..2406003 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ183_RS11800 (IZ183_11790) 2402067..2402762 - 696 WP_004240015.1 MgtC family protein -
IZ183_RS11805 (IZ183_11795) 2403112..2403306 - 195 WP_015422621.1 protein DsrB -
IZ183_RS11810 (IZ183_11800) 2403410..2403622 - 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
IZ183_RS11815 (IZ183_11805) 2404083..2404592 + 510 WP_004240013.1 YlaC family protein -
IZ183_RS11840 (IZ183_11830) 2405701..2406003 - 303 WP_004236876.1 XRE family transcriptional regulator Antitoxin
IZ183_RS11845 (IZ183_11835) 2406006..2406359 - 354 WP_032098584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IZ183_RS11850 (IZ183_11840) 2406636..2407688 + 1053 WP_062772495.1 dihydroorotase -
IZ183_RS11855 (IZ183_11845) 2407923..2408180 + 258 WP_004236879.1 biofilm formation regulator BssS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.58 Da        Isoelectric Point: 9.9631

>T181797 WP_032098584.1 NZ_CP064828:c2406359-2406006 [Morganella morganii subsp. morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T181797 NZ_CP086173:4033786-4034196 [Streptomyces fungicidicus]
GTGATCTACCTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCGAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCCGGGGCCATCGCATCCTGCTACGTGCAACGCGCCGAGTTCCTCCACAGTGCCCGGAACGGGCGCGAGTACGACG
AGATCACGGAAATGTTCACCGACCTCTACCCCGACGTGTCGGTACCGAAGAACGCGGGGCGCTGGATCGGCGCGGTGCAG
CACCGCATGGCTCGGGCAGGGGAGCATCGCAGCGCCTCGGCGGTGGACCTCCTCATCGCCGCCACCGCGGCCCACCATGG
CCTGGCTGTCCTCCACGATGATGCCGACTATCGGGCGATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACATCGCTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11108.00 Da        Isoelectric Point: 9.5930

>AT181797 WP_004236876.1 NZ_CP064828:c2406003-2405701 [Morganella morganii subsp. morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT181797 NZ_CP086173:4033568-4033789 [Streptomyces fungicidicus]
ATGTCCGTGACTCAGATTGACATCGACGACGACGCCCTGGAGCGAGCCATGGCTCTGGCCCACGTCCGGACCAAGAAGGA
GGCGGTCAACCTCGCTCTGAATTTCTATGCCGAGCAGCAGGAGCGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GTGAGTGGGGTGCCGTTGAGGACGCCGAGCGTCTGCACAGGGCGGAGAAGCGCAACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447J593

Antitoxin

Source ID Structure
AlphaFold DB J7TDD0

References