Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2017420..2018068 Replicon chromosome
Accession NZ_CP064826
Organism Morganella morganii subsp. morganii strain ZJD581

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IZ187_RS09685 Protein ID WP_186723970.1
Coordinates 2017724..2018068 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IZ187_RS09680 Protein ID WP_186723969.1
Coordinates 2017420..2017719 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ187_RS09660 (IZ187_09660) 2012649..2013074 + 426 WP_214180627.1 STM0539 family protein -
IZ187_RS09665 (IZ187_09665) 2013484..2015871 + 2388 WP_214222507.1 molybdopterin-dependent oxidoreductase -
IZ187_RS09670 (IZ187_09670) 2015868..2016497 + 630 WP_214222506.1 dimethylsulfoxide reductase subunit B -
IZ187_RS09675 (IZ187_09675) 2016494..2017366 + 873 WP_214222505.1 dimethyl sulfoxide reductase anchor subunit -
IZ187_RS09680 (IZ187_09680) 2017420..2017719 - 300 WP_186723969.1 helix-turn-helix transcriptional regulator Antitoxin
IZ187_RS09685 (IZ187_09685) 2017724..2018068 - 345 WP_186723970.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IZ187_RS09690 (IZ187_09690) 2018224..2018406 - 183 WP_214210893.1 hypothetical protein -
IZ187_RS09695 (IZ187_09695) 2018400..2021486 - 3087 WP_214222504.1 efflux RND transporter permease subunit -
IZ187_RS09700 (IZ187_09700) 2021483..2022571 - 1089 WP_214222503.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13274.20 Da        Isoelectric Point: 8.8136

>T181790 WP_186723970.1 NZ_CP064826:c2018068-2017724 [Morganella morganii subsp. morganii]
VWTVLLTDYFNEWLSEQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKNSQYPNMKELRIWHAGRAIRAFFAFDSERQAI
VLCAGDKGKNKRFYQTMIRIADEQFSSYLAAAKE

Download         Length: 345 bp

>T181790 NZ_CP086138:c87186-86779 [Bradyrhizobium barranii subsp. barranii]
ATGTATCTCATTGATACCAACGTCGTTTCCGAGGCTCGGCGCGGCTCTCCGCAGGCAACCGGCTGGCTGCGCTCGGTGGA
TCCGGCCAGCGTCTACCTGAGCACCCTCACCCTCGGCGAGATCATGCGCGGCATCGCGCTGAAGCAGAAGTCGGACCCGA
AGGTGGCCGGCCACCTTGCCGAATGGTTGCGCAAGTTGCGCCACGACCACGCCAACCGCATCCTGGCGGTGACCGACCAG
ATCTCCGTCGAGTGGGGTCGCATCGCCGCGATCCGGCCGTGTGGCGATATCGACGGGCTGATCGCCGCAACCGCGATCGT
CCACGACCTCATCCTCGTCACTCGCAATGTGGGGGATTTCGACGATACGGGCGCAACGGTGATCAATCCCTGGGAGGCGT
CGACATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11180.00 Da        Isoelectric Point: 7.0156

>AT181790 WP_186723969.1 NZ_CP064826:c2017719-2017420 [Morganella morganii subsp. morganii]
MKTLQEVIAAQPPESRERIKQLTDELVLETGLQLLREELHISQKMLATNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRVFRV

Download         Length: 300 bp

>AT181790 NZ_CP086138:c86668-86414 [Bradyrhizobium barranii subsp. barranii]
ATGGCGCTGAGCATCAAGGATCCCGAAACCGAAAAACTCGCGCGCACGCTAGCCGAGCGGACAGGGGAAACCATCACCGT
CGCGACCCGACGGGCGATCGAGGATAGGTTGCGACGGATCGGGGCCGACGCGACCAAGGCCGCGCTGATTGAGGATATGG
AAGCCATTCGGCGCCGCCTCGCTGCCCTCCCGGTCCTCGATCCACGCAGCATGGATGACATCCTCGGGTACGACGAAAAC
GGCTTGCCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References