Detailed information of TA system TA181760

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 15454..15712
• Replicon: chromosome
• Accession: NZ_CP064825
• Organism: Escherichia coli UTI89

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: IIE09_RS00075
• Protein ID: WP_001181672.1
• Coordinates: 15454..15663 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	15655..15712 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IIE09_RS00055	10699..11412	-	714	WP_001102393.1	acidic protein MsyB	-
IIE09_RS00060	11438..11842	-	405	WP_000843687.1	DUF2541 family protein	-
IIE09_RS00065	12214..14130	+	1917	WP_000516135.1	molecular chaperone DnaK	-
IIE09_RS00070	14219..15349	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
IIE09_RS00075	15454..15663	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	15655..15712	+	58	-	-	Antitoxin
IIE09_RS00080	16218..16979	+	762	WP_001274823.1	hypothetical protein	-
IIE09_RS00085	16999..18492	+	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
IIE09_RS00090	18621..19880	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T181760 WP_001181672.1 NZ_CP064825:c15663-15454 [Escherichia coli UTI89]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T181760 NZ_CP086128:327254-327622 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT181760 NZ_CP064825:15655-15712 [Escherichia coli UTI89]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin