Detailed information of TA system TA181737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4084339..4084928
• Replicon: chromosome
• Accession: NZ_CP064794
• Organism: Xanthomonas oryzae pv. oryzicola strain HGA4

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: IZG20_RS18550
• Protein ID: WP_012443754.1
• Coordinates: 4084339..4084620 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IZG20_RS18555
• Protein ID: WP_011260746.1
• Coordinates: 4084638..4084928 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZG20_RS18545	4081983..4084244	+	2262	WP_048483857.1	exodeoxyribonuclease V subunit alpha	-
IZG20_RS18550	4084339..4084620	+	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IZG20_RS18555	4084638..4084928	+	291	WP_011260746.1	HigA family addiction module antitoxin	Antitoxin
IZG20_RS18560	4085881..4087275	+	1395	WP_024712138.1	type III secretion system effector XopQ	-
IZG20_RS18565	4087378..4087565	-	188	Protein_3524	hypothetical protein	-
IZG20_RS18570	4087727..4088059	-	333	WP_011260743.1	hypothetical protein	-
IZG20_RS18575	4088314..4088619	+	306	WP_224229802.1	hypothetical protein	-
IZG20_RS18580	4088769..4089191	+	423	WP_048484129.1	PAAR domain-containing protein	-
IZG20_RS18585	4089194..4089670	+	477	WP_048483859.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11098.89 Da
• Isoelectric Point: 10.5318

>T181737 WP_012443754.1 NZ_CP064794:4084339-4084620 [Xanthomonas oryzae pv. oryzicola]
MIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T181737 NZ_CP086118:870553-870966 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT181737 WP_011260746.1 NZ_CP064794:4084638-4084928 [Xanthomonas oryzae pv. oryzicola]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT181737 NZ_CP086118:870306-870572 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5