Detailed information of TA system TA181732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3808131..3808791
• Replicon: chromosome
• Accession: NZ_CP064784
• Organism: Klebsiella sp. BDA134-6

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IYV58_RS17575
• Protein ID: WP_112166274.1
• Coordinates: 3808438..3808791 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IYV58_RS17570
• Protein ID: WP_087829043.1
• Coordinates: 3808131..3808433 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IYV58_RS17565	3807444..3807857	+	414	WP_195729169.1	DNA mismatch endonuclease Vsr	-
IYV58_RS17570	3808131..3808433	-	303	WP_087829043.1	XRE family transcriptional regulator	Antitoxin
IYV58_RS17575	3808438..3808791	-	354	WP_112166274.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IYV58_RS17580	3809176..3810594	-	1419	WP_004122238.1	heavy metal sensor histidine kinase	-
IYV58_RS17585	3810591..3811262	-	672	WP_004122240.1	heavy metal response regulator transcription factor	-
IYV58_RS17590	3811402..3812028	+	627	WP_112166276.1	hypothetical protein	-
IYV58_RS17595	3812043..3812651	+	609	WP_004122247.1	cytochrome b/b6 domain-containing protein	-
IYV58_RS17600	3812641..3813408	+	768	WP_004122251.1	molybdopterin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3793525..3822440	28915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (16-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13521.36 Da
• Isoelectric Point: 8.9066

>T181732 WP_112166274.1 NZ_CP064784:c3808791-3808438 [Klebsiella sp. BDA134-6]
VWMIKTTDTFERWFTSLNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVSNEKRFYDEILPVADREYTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T181732 NZ_CP086113:137518-137853 [Skermanella rosea]
ATGGCCGTGCCAGGTCGCGGCGATCTGGTCTGGATCGATTCTACGCCCAACGCGGTCCACGAGCAGGCCGGGCGACGACC
GGCTCTGGTGCTCTCGCCCCGGGAGTACCACCGACTCACGAAATTCGCCGTCGTGTGCCCGATCACCAGCACGATCAAGG
GGCACCCTTTCGAGGTCGTTCTGCCCATGGGCCTGGGTTTCTCCGGTGCCGTGCTGACCGACCAGGTCAAAAGCATCGAC
CGCAATGCAAGGCGGATCGAACCGGTTGGGAAGGCGCCCGACAGTGTGATCCAGGAGGTGCTGGCTCGGATCGGCCCTCT
GCTCGGAATTCAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11026.78 Da
• Isoelectric Point: 5.1992

>AT181732 WP_087829043.1 NZ_CP064784:c3808433-3808131 [Klebsiella sp. BDA134-6]
MGRTLEQLIADEKPEVVAEAEAMAKDILLNIHLAELRERVQKTQVEMAQELGIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLSLNVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT181732 NZ_CP086113:137282-137518 [Skermanella rosea]
ATGCGTACTGAAATCGCTAAATGGGGCAATAGCCTGGCGGTGCGCCTGCCGAAGCGGATCATCGAGCAGGCCGGGCTCAC
GGAAGGCGCGGCCATCGAACTGGCCGTTGAGTCTGGCGCGGTCGTCCTGCGTCCAGCTCGGCCGCGCTACACCATCGATG
AGCTGCTGGCTGGCATGACACCGGAGAACCAGCACGAGAGCTTCGATGATGGCCCGGTCGGCCACGAGCTGATCTGA