Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2413945..2414581 Replicon chromosome
Accession NZ_CP064781
Organism Azospira restricta strain DSM 18626

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IWH25_RS11870 Protein ID WP_203386011.1
Coordinates 2414255..2414581 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IWH25_RS11865 Protein ID WP_203386010.1
Coordinates 2413945..2414262 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IWH25_RS11850 2409808..2410710 - 903 WP_203386007.1 branched-chain amino acid ABC transporter permease -
IWH25_RS11855 2410779..2412095 - 1317 WP_203386008.1 ABC transporter substrate-binding protein -
IWH25_RS11860 2412105..2413463 - 1359 WP_203386009.1 ABC transporter substrate-binding protein -
IWH25_RS11865 2413945..2414262 - 318 WP_203386010.1 helix-turn-helix domain-containing protein Antitoxin
IWH25_RS11870 2414255..2414581 - 327 WP_203386011.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IWH25_RS11875 2415176..2416402 - 1227 WP_203386012.1 MFS transporter -
IWH25_RS11880 2416847..2417293 + 447 WP_203386013.1 peptide-methionine (R)-S-oxide reductase MsrB -
IWH25_RS11885 2417293..2417811 + 519 WP_203386014.1 peptide-methionine (S)-S-oxide reductase MsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-96)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12557.57 Da        Isoelectric Point: 9.9558

>T181720 WP_203386011.1 NZ_CP064781:c2414581-2414255 [Azospira restricta]
MSFNIEYFHERVLHEVESWPVDVLADYARLVELLAEHGPSLRLPHSRAFGDGLFELRPKGRSGIGRAFYCFLLGKRVIVL
HAFIKKTQQTPDRELKLARQRLKEVRDA

Download         Length: 327 bp

>T181720 NZ_CP086111:1858648-1858938 [Skermanella rosea]
TTGATTGAAATTCAGCAGACCGATCTATTCGCCGCATGGATCGAGTCAGTTCGTGACGATCGCGCCCGTCTGCGGGTCGA
GACGCGGATTCGGCGACTGCAACTTGGCAATCCCGGAGACGTCAATCCAGTCGGAGAAGGCGTGTCGGAAATGAGGATCG
ACTATGGGCCGGGCTACAGAGTGTATTTCACCTGCCGGGGCCGGACGGTGATAGTCCTCCTGGCCGGCGGAGACAAGCGT
ACCCAGGATCTGGATATCGCGGCGGCTATCCGTCTGGCCCGGGAGCTTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11449.24 Da        Isoelectric Point: 10.2189

>AT181720 WP_203386010.1 NZ_CP064781:c2414262-2413945 [Azospira restricta]
MPDLKFNPVAHDHKKFLAKAQKRDGFTEAYEALALEYQLASQMLKARARAGLTQDAVAERMGTTKSAISRLESAGKHAPS
LATLKRYAEAVGCDLQVKLVPHKAA

Download         Length: 318 bp

>AT181720 NZ_CP086111:1858949-1859254 [Skermanella rosea]
ATGTCCAAGACCGAAACCCGTCCATGGGACATCGTAGACAGCCTCACCAACGAGGAGCGTATCGCTGCATACCTGGAAGC
TGTCCTGGAGGACGGCGATCCGGAACTTGTCGCGGCAGCGCTCGGCGATATCGCGCGGGCGAAAGGCATGACGGACATAG
CGCGCCGCACCGGGCTGGGGCGACAGAGTCTGTACAAGGCCCTGGCGCCGGGCGGCAATCCGGAATTCGCAACCGTGTTG
AAGGTGATCCGCTCGCTCGGATTGCGCCTCACCGTCACCGTGGACCCTGAAGGTCCAGGAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References