Detailed information of TA system TA181701

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2199605..2199883
• Replicon: chromosome
• Accession: NZ_CP064772
• Organism: Staphylococcus aureus strain TCH32767

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IXH55_RS10695
• Protein ID: WP_001802298.1
• Coordinates: 2199605..2199709 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2199705..2199883 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXH55_RS10680 (IXH55_10630)	2196402..2197184	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IXH55_RS10685 (IXH55_10635)	2197252..2198109	+	858	WP_000370923.1	HAD family hydrolase	-
IXH55_RS10690 (IXH55_10640)	2198767..2198925	-	159	WP_001792784.1	hypothetical protein	-
IXH55_RS10695 (IXH55_10645)	2199605..2199709	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2199705..2199883	-	179	-	-	Antitoxin
IXH55_RS10705 (IXH55_10650)	2200142..2201233	-	1092	WP_000495669.1	hypothetical protein	-
IXH55_RS10710 (IXH55_10655)	2201499..2202476	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IXH55_RS10715 (IXH55_10660)	2202478..2202798	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IXH55_RS10720 (IXH55_10665)	2202950..2203615	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T181701 WP_001802298.1 NZ_CP064772:2199605-2199709 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T181701 NZ_CP086102:c5222399-5222139 [Streptomyces anulatus]
GTGAAGTTCGTGTGGGACCAGTCGTCCTGGGACGACTACGTGTGGTGGCAGAACCAGGATCGCAAGGTCCTCAAAAGGAT
CAACGCGCTGCTCCAGGACATCGCCCGGAACGGCAACGAGGGAATGGGCAAGCCGGAACCCCTGAAACACGGCTTCCAGG
GGTACTGGTCGCGCCGCATCACCGAGGAGCACCGCCTCATCTACAAGGTGGTCGACGACGAGGTCCGCGTCGCCGCCTGC
CGCTACCACTACGGCCGCTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT181701 NZ_CP064772:c2199883-2199705 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin