Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1939744..1940261 | Replicon | chromosome |
| Accession | NZ_CP064772 | ||
| Organism | Staphylococcus aureus strain TCH32767 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | IXH55_RS09340 | Protein ID | WP_000113265.1 |
| Coordinates | 1939995..1940261 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IXH55_RS09335 | Protein ID | WP_000584499.1 |
| Coordinates | 1939744..1939995 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IXH55_RS09305 (IXH55_09260) | 1935442..1936161 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IXH55_RS09310 (IXH55_09265) | 1936158..1936889 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IXH55_RS09315 (IXH55_09270) | 1936986..1938236 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| IXH55_RS09320 (IXH55_09275) | 1938491..1938853 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IXH55_RS09325 (IXH55_09280) | 1938872..1939471 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| IXH55_RS09330 (IXH55_09285) | 1939499..1939579 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| IXH55_RS09335 (IXH55_09290) | 1939744..1939995 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IXH55_RS09340 (IXH55_09295) | 1939995..1940261 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| IXH55_RS09345 (IXH55_09300) | 1940296..1940367 | + | 72 | Protein_1846 | hypothetical protein | - |
| IXH55_RS09350 (IXH55_09305) | 1940556..1942103 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IXH55_RS09355 (IXH55_09310) | 1942289..1942756 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| IXH55_RS09360 (IXH55_09315) | 1942840..1943022 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| IXH55_RS09365 (IXH55_09320) | 1943239..1944063 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| IXH55_RS09370 (IXH55_09325) | 1944297..1944833 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T181699 WP_000113265.1 NZ_CP064772:1939995-1940261 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T181699 NZ_CP086101:c3884785-3884375 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGAGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGAGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT181699 WP_000584499.1 NZ_CP064772:1939744-1939995 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT181699 NZ_CP086101:c3885032-3884766 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|