Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1914537..1914721 Replicon chromosome
Accession NZ_CP064772
Organism Staphylococcus aureus strain TCH32767

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag IXH55_RS09205 Protein ID WP_000482652.1
Coordinates 1914537..1914644 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1914661..1914721 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXH55_RS09180 (IXH55_09135) 1909899..1910372 + 474 WP_000456486.1 GyrI-like domain-containing protein -
IXH55_RS09185 (IXH55_09140) 1910495..1911706 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
IXH55_RS09190 (IXH55_09145) 1911888..1912547 - 660 WP_000831298.1 membrane protein -
IXH55_RS09195 (IXH55_09150) 1912607..1913749 - 1143 WP_001176863.1 glycerate kinase -
IXH55_RS09200 (IXH55_09155) 1914017..1914403 + 387 WP_000779360.1 flippase GtxA -
IXH55_RS09205 (IXH55_09160) 1914537..1914644 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1914661..1914721 - 61 - - Antitoxin
IXH55_RS09210 (IXH55_09165) 1915347..1917110 + 1764 WP_001064825.1 ABC transporter ATP-binding protein -
IXH55_RS09215 (IXH55_09170) 1917135..1918868 + 1734 WP_000486487.1 ABC transporter ATP-binding protein -
IXH55_RS09220 (IXH55_09175) 1919135..1919266 + 132 WP_223197975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T181697 WP_000482652.1 NZ_CP064772:1914537-1914644 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T181697 NZ_CP086101:c1036746-1036528 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACTATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 61 bp

>AT181697 NZ_CP064772:c1914721-1914661 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References