Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3693338..3693560 Replicon chromosome
Accession NZ_CP064680
Organism Escherichia coli K-12 strain CETR1G40

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag IVL01_RS17915 Protein ID WP_000141634.1
Coordinates 3693338..3693445 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3693494..3693560 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL01_RS17890 3688591..3689343 - 753 Protein_3494 cellulose biosynthesis protein BcsQ -
IVL01_RS17895 3689355..3689543 - 189 WP_001063318.1 YhjR family protein -
IVL01_RS17900 3689816..3691387 + 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
IVL01_RS17905 3691384..3691575 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
IVL01_RS17910 3691572..3693251 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
IVL01_RS17915 3693338..3693445 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 3693494..3693560 + 67 - - Antitoxin
IVL01_RS17920 3693921..3695192 + 1272 WP_001295225.1 transporter -
IVL01_RS17925 3695222..3696226 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
IVL01_RS17930 3696223..3697206 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
IVL01_RS17935 3697217..3698119 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T181531 WP_000141634.1 NZ_CP064680:c3693445-3693338 [Escherichia coli K-12]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T181531 NZ_CP085947:c1516282-1516016 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAGCTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAACAAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGA
AACCTTTTAGGGAATGCCACATCAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 67 bp

>AT181531 NZ_CP064680:3693494-3693560 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References