181528

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3161208..3161901 Replicon chromosome
Accession NZ_CP064680
Organism Escherichia coli K-12 strain CETR1G40

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IVL01_RS15335 Protein ID WP_000415584.1
Coordinates 3161605..3161901 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IVL01_RS15330 Protein ID WP_000650107.1
Coordinates 3161208..3161603 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL01_RS15320 3157072..3159330 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
IVL01_RS15325 3159468..3161075 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IVL01_RS15330 3161208..3161603 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IVL01_RS15335 3161605..3161901 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IVL01_RS15340 3162106..3162588 - 483 WP_000183505.1 transcriptional regulator -
IVL01_RS15345 3162641..3163033 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IVL01_RS15350 3163185..3163844 + 660 WP_001221495.1 two-component system response regulator QseB -
IVL01_RS15355 3163841..3165190 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IVL01_RS15360 3165236..3165568 - 333 WP_000917684.1 DUF2645 family protein -
IVL01_RS15365 3165887..3166468 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IVL01_RS15370 3166499..3166813 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T181528 WP_000415584.1 NZ_CP064680:c3161901-3161605 [Escherichia coli K-12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T181528 NZ_CP085945:5081690-5082082 [Mycobacterium intracellulare]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT181528 WP_000650107.1 NZ_CP064680:c3161603-3161208 [Escherichia coli K-12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT181528 NZ_CP085945:5081415-5081690 [Mycobacterium intracellulare]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References