Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3161210..3161903 Replicon chromosome
Accession NZ_CP064678
Organism Escherichia coli K-12 strain CETR3G40

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IVL03_RS15330 Protein ID WP_000415584.1
Coordinates 3161607..3161903 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IVL03_RS15325 Protein ID WP_000650107.1
Coordinates 3161210..3161605 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL03_RS15315 3157074..3159332 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
IVL03_RS15320 3159470..3161077 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IVL03_RS15325 3161210..3161605 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IVL03_RS15330 3161607..3161903 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IVL03_RS15335 3162108..3162590 - 483 WP_000183505.1 transcriptional regulator -
IVL03_RS15340 3162643..3163035 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IVL03_RS15345 3163187..3163846 + 660 WP_001221495.1 two-component system response regulator QseB -
IVL03_RS15350 3163843..3165192 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IVL03_RS15355 3165238..3165570 - 333 WP_000917684.1 DUF2645 family protein -
IVL03_RS15360 3165889..3166470 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IVL03_RS15365 3166501..3166815 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T181442 WP_000415584.1 NZ_CP064678:c3161903-3161607 [Escherichia coli K-12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T181442 NZ_CP085860:c1077068-1076865 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT181442 WP_000650107.1 NZ_CP064678:c3161605-3161210 [Escherichia coli K-12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT181442 NZ_CP085860:c1077487-1077119 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GATGATACCTATACGCTGTTCAGCAGTTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References