Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4529597..4530351 Replicon chromosome
Accession NZ_CP064674
Organism Salmonella sp. SJTUF14076

Toxin (Protein)


Gene name higB Uniprot ID A0A4Y6MJG6
Locus tag HU143_RS21715 Protein ID WP_000558165.1
Coordinates 4529597..4529908 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HU143_RS21720 Protein ID WP_001259009.1
Coordinates 4529905..4530351 (+) Length 149 a.a.

Genomic Context

HU143_RS21685HU143_RS21690HU143_RS21695HU143_RS21710HU143_RS21715HU143_RS21720HU143_RS21700HU143_RS21705HU143_RS21725HU143_RS21730HU143_RS21735HU143_RS21740HU143_RS21745HU143_RS21750
Location: 4525263..4526165 (903 bp)
Type: Others
Protein ID: WP_051129234.1
Location: 4526162..4526797 (636 bp)
Type: Others
Protein ID: WP_000829028.1
Location: 4526794..4527723 (930 bp)
Type: Others
Protein ID: WP_000027730.1
Location: 4528582..4529511 (930 bp)
Type: Others
Protein ID: WP_001162861.1
Location: 4529597..4529908 (312 bp)
Type: Toxin
Protein ID: WP_000558165.1
Location: 4529905..4530351 (447 bp)
Type: Antitoxin
Protein ID: WP_001259009.1
Location: 4527761..4528135 (375 bp)
Type: Others
Protein ID: WP_000238494.1
Location: 4528135..4528377 (243 bp)
Type: Others
Protein ID: WP_001523745.1
Location: 4530366..4531307 (942 bp)
Type: Others
Protein ID: WP_001518251.1
Location: 4531352..4531789 (438 bp)
Type: Others
Protein ID: WP_000560969.1
Location: 4531786..4532658 (873 bp)
Type: Others
Protein ID: WP_000921423.1
Location: 4532652..4533251 (600 bp)
Type: Others
Protein ID: WP_023227076.1
Location: 4533442..4534245 (804 bp)
Type: Others
Protein ID: WP_000059689.1
Location: 4534279..4535175 (897 bp)
Type: Others
Protein ID: WP_023227075.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HU143_RS216854525263..4526165+903WP_051129234.1formate dehydrogenase subunit beta-
HU143_RS216904526162..4526797+636WP_000829028.1formate dehydrogenase cytochrome b556 subunit-
HU143_RS216954526794..4527723+930WP_000027730.1formate dehydrogenase accessory protein FdhE-
HU143_RS217004527761..4528135-375WP_000238494.1type II toxin-antitoxin system VapC family toxin-
HU143_RS217054528135..4528377-243WP_001523745.1ribbon-helix-helix domain-containing protein-
HU143_RS217104528582..4529511+930WP_001162861.1alpha/beta hydrolase-
HU143_RS217154529597..4529908+312WP_000558165.1type II toxin-antitoxin system HigB family toxinToxin
HU143_RS217204529905..4530351+447WP_001259009.1type II toxin-antitoxin system HigA family antitoxinAntitoxin
HU143_RS217254530366..4531307-942WP_001518251.1fatty acid biosynthesis protein FabY-
HU143_RS217304531352..4531789-438WP_000560969.1D-tyrosyl-tRNA(Tyr) deacylase-
HU143_RS217354531786..4532658-873WP_000921423.1virulence factor BrkB family protein-
HU143_RS217404532652..4533251-600WP_023227076.1glucose-1-phosphatase-
HU143_RS217454533442..4534245-804WP_000059689.1DeoR/GlpR family DNA-binding transcription regulator-
HU143_RS217504534279..4535175-897WP_023227075.1sugar kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12433.34 Da        Isoelectric Point: 8.4020

>T181409 WP_000558165.1 NZ_CP064674:4529597-4529908 [Salmonella sp. SJTUF14076]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Download         Length: 312 bp

>T181409 NZ_CP085841:2790771-2790911 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT181409 WP_001259009.1 NZ_CP064674:4529905-4530351 [Salmonella sp. SJTUF14076]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT181409 NZ_CP085841:c2791042-2790844 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGA
CGGTGACCAATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAAACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4Y6MJG6

Antitoxin

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Source
ID
Structure
No matching records found

References