Detailed information of TA system TA181389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4594425..4595179
• Replicon: chromosome
• Accession: NZ_CP064672
• Organism: Salmonella sp. SJTUF14146

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A4Y6MJG6
• Locus tag: IVP14_RS22080
• Protein ID: WP_000558165.1
• Coordinates: 4594425..4594736 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IVP14_RS22085
• Protein ID: WP_001259009.1
• Coordinates: 4594733..4595179 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP14_RS22050	4590091..4590993	+	903	WP_051129234.1	formate dehydrogenase subunit beta	-
IVP14_RS22055	4590990..4591625	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
IVP14_RS22060	4591622..4592551	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IVP14_RS22065	4592589..4592963	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
IVP14_RS22070	4592963..4593205	-	243	WP_001523745.1	ribbon-helix-helix domain-containing protein	-
IVP14_RS22075	4593410..4594339	+	930	WP_001162861.1	alpha/beta hydrolase	-
IVP14_RS22080	4594425..4594736	+	312	WP_000558165.1	type II toxin-antitoxin system HigB family toxin	Toxin
IVP14_RS22085	4594733..4595179	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
IVP14_RS22090	4595194..4596135	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IVP14_RS22095	4596180..4596617	-	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
IVP14_RS22100	4596614..4597486	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IVP14_RS22105	4597480..4598079	-	600	WP_023227076.1	glucose-1-phosphatase	-
IVP14_RS22110	4598270..4599073	-	804	WP_000059689.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVP14_RS22115	4599107..4600003	-	897	WP_023227075.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12433.34 Da
• Isoelectric Point: 8.4020

>T181389 WP_000558165.1 NZ_CP064672:4594425-4594736 [Salmonella sp. SJTUF14146]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Nucleotide

• Length: 312 bp

>T181389 NZ_CP085824:662546-662914 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT181389 WP_001259009.1 NZ_CP064672:4594733-4595179 [Salmonella sp. SJTUF14146]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT181389 NZ_CP085824:662328-662549 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A4Y6MJG6