Detailed information of TA system TA181347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4552633..4553387
• Replicon: chromosome
• Accession: NZ_CP064666
• Organism: Salmonella sp. SJTUF14154

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A4Y6MJG6
• Locus tag: IVP16_RS21815
• Protein ID: WP_000558165.1
• Coordinates: 4552633..4552944 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IVP16_RS21820
• Protein ID: WP_001259009.1
• Coordinates: 4552941..4553387 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP16_RS21785	4548299..4549201	+	903	WP_051129234.1	formate dehydrogenase subunit beta	-
IVP16_RS21790	4549198..4549833	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
IVP16_RS21795	4549830..4550759	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IVP16_RS21800	4550797..4551171	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
IVP16_RS21805	4551171..4551413	-	243	WP_001523745.1	ribbon-helix-helix domain-containing protein	-
IVP16_RS21810	4551618..4552547	+	930	WP_001162861.1	alpha/beta hydrolase	-
IVP16_RS21815	4552633..4552944	+	312	WP_000558165.1	type II toxin-antitoxin system HigB family toxin	Toxin
IVP16_RS21820	4552941..4553387	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
IVP16_RS21825	4553402..4554343	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IVP16_RS21830	4554388..4554825	-	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
IVP16_RS21835	4554822..4555694	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IVP16_RS21840	4555688..4556287	-	600	WP_023227076.1	glucose-1-phosphatase	-
IVP16_RS21845	4556478..4557281	-	804	WP_000059689.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVP16_RS21850	4557315..4558211	-	897	WP_023227075.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12433.34 Da
• Isoelectric Point: 8.4020

>T181347 WP_000558165.1 NZ_CP064666:4552633-4552944 [Salmonella sp. SJTUF14154]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Nucleotide

• Length: 312 bp

>T181347 NZ_CP085821:c3530645-3530247 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT181347 WP_001259009.1 NZ_CP064666:4552941-4553387 [Salmonella sp. SJTUF14154]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT181347 NZ_CP085821:c3530872-3530645 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A4Y6MJG6