Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4620491..4621245 Replicon chromosome
Accession NZ_CP064663
Organism Salmonella sp. SJTUF14170

Toxin (Protein)


Gene name higB Uniprot ID A0A4Y6MJG6
Locus tag IVP17_RS22340 Protein ID WP_000558165.1
Coordinates 4620491..4620802 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IVP17_RS22345 Protein ID WP_001259009.1
Coordinates 4620799..4621245 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP17_RS22310 4616157..4617059 + 903 WP_051129234.1 formate dehydrogenase subunit beta -
IVP17_RS22315 4617056..4617691 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
IVP17_RS22320 4617688..4618617 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IVP17_RS22325 4618655..4619029 - 375 WP_064163215.1 type II toxin-antitoxin system VapC family toxin -
IVP17_RS22330 4619029..4619271 - 243 WP_001523745.1 ribbon-helix-helix domain-containing protein -
IVP17_RS22335 4619476..4620405 + 930 WP_001162861.1 alpha/beta hydrolase -
IVP17_RS22340 4620491..4620802 + 312 WP_000558165.1 type II toxin-antitoxin system HigB family toxin Toxin
IVP17_RS22345 4620799..4621245 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
IVP17_RS22350 4621260..4622201 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IVP17_RS22355 4622246..4622683 - 438 WP_000560969.1 D-tyrosyl-tRNA(Tyr) deacylase -
IVP17_RS22360 4622680..4623552 - 873 WP_000921423.1 virulence factor BrkB family protein -
IVP17_RS22365 4623546..4624145 - 600 WP_023227076.1 glucose-1-phosphatase -
IVP17_RS22370 4624336..4625139 - 804 WP_000059689.1 DeoR/GlpR family DNA-binding transcription regulator -
IVP17_RS22375 4625173..4626069 - 897 WP_023227075.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12433.34 Da        Isoelectric Point: 8.4020

>T181328 WP_000558165.1 NZ_CP064663:4620491-4620802 [Salmonella sp. SJTUF14170]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Download         Length: 312 bp

>T181328 NZ_CP085820:c1495869-1495384 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT181328 WP_001259009.1 NZ_CP064663:4620799-4621245 [Salmonella sp. SJTUF14170]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT181328 NZ_CP085820:c1496144-1495857 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4Y6MJG6


Antitoxin

Source ID Structure

References