Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4620554..4621308 Replicon chromosome
Accession NZ_CP064661
Organism Salmonella sp. SJTUF14178

Toxin (Protein)


Gene name higB Uniprot ID A0A4Y6MJG6
Locus tag IVP18_RS22340 Protein ID WP_000558165.1
Coordinates 4620554..4620865 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IVP18_RS22345 Protein ID WP_001259009.1
Coordinates 4620862..4621308 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP18_RS22310 4616220..4617122 + 903 WP_051129234.1 formate dehydrogenase subunit beta -
IVP18_RS22315 4617119..4617754 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
IVP18_RS22320 4617751..4618680 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IVP18_RS22325 4618718..4619092 - 375 WP_064163215.1 type II toxin-antitoxin system VapC family toxin -
IVP18_RS22330 4619092..4619334 - 243 WP_001523745.1 ribbon-helix-helix domain-containing protein -
IVP18_RS22335 4619539..4620468 + 930 WP_001162861.1 alpha/beta hydrolase -
IVP18_RS22340 4620554..4620865 + 312 WP_000558165.1 type II toxin-antitoxin system HigB family toxin Toxin
IVP18_RS22345 4620862..4621308 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
IVP18_RS22350 4621323..4622264 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IVP18_RS22355 4622309..4622746 - 438 WP_000560969.1 D-tyrosyl-tRNA(Tyr) deacylase -
IVP18_RS22360 4622743..4623615 - 873 WP_000921423.1 virulence factor BrkB family protein -
IVP18_RS22365 4623609..4624208 - 600 WP_023227076.1 glucose-1-phosphatase -
IVP18_RS22370 4624399..4625202 - 804 WP_000059689.1 DeoR/GlpR family DNA-binding transcription regulator -
IVP18_RS22375 4625236..4626132 - 897 WP_023227075.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12433.34 Da        Isoelectric Point: 8.4020

>T181308 WP_000558165.1 NZ_CP064661:4620554-4620865 [Salmonella sp. SJTUF14178]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE

Download         Length: 312 bp

>T181308 NZ_CP085818:c4366316-4365831 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT181308 WP_001259009.1 NZ_CP064661:4620862-4621308 [Salmonella sp. SJTUF14178]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT181308 NZ_CP085818:c4366591-4366304 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4Y6MJG6


Antitoxin

Source ID Structure

References