Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 36220..36739 | Replicon | plasmid unnamed_4 |
Accession | NZ_CP064428 | ||
Organism | Enterococcus faecium strain PR01996-12 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | IUH71_RS15435 | Protein ID | WP_000588503.1 |
Coordinates | 36482..36739 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | IUH71_RS15430 | Protein ID | WP_000388479.1 |
Coordinates | 36220..36489 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IUH71_RS15400 (IUH71_15400) | 31288..32241 | + | 954 | WP_002287760.1 | IS30 family transposase | - |
IUH71_RS15405 (IUH71_15405) | 32219..33694 | + | 1476 | WP_000443455.1 | RNA-directed DNA polymerase | - |
IUH71_RS15410 (IUH71_15410) | 34032..34172 | + | 141 | Protein_37 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
IUH71_RS15415 (IUH71_15415) | 34231..34911 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
IUH71_RS15420 (IUH71_15420) | 35029..35709 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
IUH71_RS15425 (IUH71_15425) | 35910..36089 | + | 180 | WP_001120991.1 | hypothetical protein | - |
IUH71_RS15430 (IUH71_15430) | 36220..36489 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
IUH71_RS15435 (IUH71_15435) | 36482..36739 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
IUH71_RS15440 (IUH71_15440) | 37198..38202 | + | 1005 | WP_000455809.1 | hypothetical protein | - |
IUH71_RS15445 (IUH71_15445) | 38367..38981 | - | 615 | WP_001261742.1 | recombinase family protein | - |
IUH71_RS15450 (IUH71_15450) | 39431..40756 | + | 1326 | WP_000969590.1 | Y-family DNA polymerase | - |
IUH71_RS15455 (IUH71_15455) | 40749..41099 | + | 351 | WP_000568378.1 | hypothetical protein | - |
IUH71_RS15460 (IUH71_15460) | 41096..41275 | + | 180 | WP_001021554.1 | hypothetical protein | - |
IUH71_RS15465 (IUH71_15465) | 41411..41701 | + | 291 | WP_000026576.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Non-Mobilizable plasmid | erm(B) / ant(6)-Ia / aph(3')-III / VanHAX | - | 1..43518 | 43518 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T181269 WP_000588503.1 NZ_CP064428:36482-36739 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T181269 NZ_CP085816:c3599728-3599420 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT181269 WP_000388479.1 NZ_CP064428:36220-36489 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT181269 NZ_CP085816:c3599970-3599731 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |