Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5521281..5521876 Replicon chromosome
Accession NZ_CP064399
Organism Pseudomonas aeruginosa strain QZPH41

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ITG68_RS25750 Protein ID WP_180361170.1
Coordinates 5521598..5521876 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ITG68_RS25745 Protein ID WP_003099268.1
Coordinates 5521281..5521586 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG68_RS25720 (ITG68_25710) 5516358..5516693 + 336 WP_128531164.1 hypothetical protein -
ITG68_RS31010 5516785..5516874 + 90 Protein_5092 NUDIX domain-containing protein -
ITG68_RS25730 (ITG68_25720) 5517230..5517811 - 582 WP_128531166.1 hypothetical protein -
ITG68_RS25735 (ITG68_25725) 5517812..5518243 - 432 WP_128531167.1 response regulator -
ITG68_RS25740 (ITG68_25730) 5518240..5520015 - 1776 WP_128531168.1 HAMP domain-containing sensor histidine kinase -
ITG68_RS25745 (ITG68_25735) 5521281..5521586 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
ITG68_RS25750 (ITG68_25740) 5521598..5521876 - 279 WP_180361170.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITG68_RS31015 5521929..5522057 - 129 Protein_5098 integrase -
ITG68_RS25755 (ITG68_25745) 5522205..5524433 + 2229 WP_031633241.1 TonB-dependent receptor -
ITG68_RS25760 (ITG68_25750) 5524503..5525150 - 648 WP_003095021.1 carbonate dehydratase -
ITG68_RS25765 (ITG68_25755) 5525212..5526450 - 1239 WP_222831319.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10680.21 Da        Isoelectric Point: 7.8937

>T181183 WP_180361170.1 NZ_CP064399:c5521876-5521598 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAIFTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T181183 NZ_CP085809:c3885100-3884699 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT181183 WP_003099268.1 NZ_CP064399:c5521586-5521281 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT181183 NZ_CP085809:c3885347-3885081 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References