Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4837403..4838084 Replicon chromosome
Accession NZ_CP064399
Organism Pseudomonas aeruginosa strain QZPH41

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag ITG68_RS22530 Protein ID WP_003111825.1
Coordinates 4837719..4838084 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag ITG68_RS22525 Protein ID WP_003159602.1
Coordinates 4837403..4837726 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG68_RS22500 (ITG68_22490) 4833322..4833960 + 639 WP_003119439.1 hypothetical protein -
ITG68_RS22505 (ITG68_22495) 4834203..4834538 + 336 WP_023102290.1 TM2 domain-containing protein -
ITG68_RS22510 (ITG68_22500) 4834712..4835230 + 519 WP_010793873.1 PAAR domain-containing protein -
ITG68_RS22515 (ITG68_22505) 4835227..4835928 + 702 WP_003159604.1 VRR-NUC domain-containing protein -
ITG68_RS22520 (ITG68_22510) 4835945..4837033 + 1089 WP_003159603.1 DUF3396 domain-containing protein -
ITG68_RS22525 (ITG68_22515) 4837403..4837726 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
ITG68_RS22530 (ITG68_22520) 4837719..4838084 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITG68_RS22535 (ITG68_22525) 4838377..4838637 - 261 WP_052155056.1 hypothetical protein -
ITG68_RS22540 (ITG68_22530) 4838844..4839116 + 273 WP_222831262.1 hypothetical protein -
ITG68_RS22545 (ITG68_22535) 4839146..4839571 - 426 WP_003116492.1 VOC family protein -
ITG68_RS22550 (ITG68_22540) 4839672..4840556 + 885 WP_003085663.1 LysR substrate-binding domain-containing protein -
ITG68_RS22555 (ITG68_22545) 4840529..4841482 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
ITG68_RS22560 (ITG68_22550) 4841703..4842137 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4808376..4839116 30740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T181181 WP_003111825.1 NZ_CP064399:c4838084-4837719 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T181181 NZ_CP085809:3714496-3715023 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACAAAAACCTACGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT181181 WP_003159602.1 NZ_CP064399:c4837726-4837403 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT181181 NZ_CP085809:3714209-3714499 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGATTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References