Detailed information of TA system TA181135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2581858..2582437
• Replicon: chromosome
• Accession: NZ_CP064389
• Organism: Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IUJ40_RS13235
• Protein ID: WP_001025401.1
• Coordinates: 2582192..2582437 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2581858..2582223 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ40_RS13195 (2578601)	2578601..2579158	-	558	WP_000645042.1	DUF2815 family protein	-
IUJ40_RS13200 (2579184)	2579184..2580350	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
IUJ40_RS13205 (2580347)	2580347..2580709	-	363	WP_000985976.1	hypothetical protein	-
IUJ40_RS13210 (2580724)	2580724..2581047	-	324	WP_000174994.1	hypothetical protein	-
IUJ40_RS13215 (2581126)	2581126..2581287	-	162	WP_001285963.1	DUF1270 family protein	-
IUJ40_RS13220 (2581300)	2581300..2581563	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
IUJ40_RS13225 (2581588)	2581588..2581803	-	216	WP_001036302.1	hypothetical protein	-
IUJ40_RS13230 (2581858)	2581858..2582223	+	366	WP_001128433.1	hypothetical protein	Antitoxin
IUJ40_RS13235 (2582192)	2582192..2582437	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IUJ40_RS13240 (2582493)	2582493..2582702	+	210	WP_000642492.1	hypothetical protein	-
IUJ40_RS13245 (2582692)	2582692..2582835	-	144	WP_000939498.1	hypothetical protein	-
IUJ40_RS13250 (2582864)	2582864..2583640	-	777	WP_140045524.1	Rha family transcriptional regulator	-
IUJ40_RS13255 (2583656)	2583656..2583874	-	219	WP_001198673.1	helix-turn-helix transcriptional regulator	-
IUJ40_RS13260 (2584016)	2584016..2584735	+	720	WP_000358224.1	XRE family transcriptional regulator	-
IUJ40_RS13265 (2584805)	2584805..2584987	+	183	WP_000705240.1	hypothetical protein	-
IUJ40_RS13270 (2585023)	2585023..2585169	+	147	WP_001013104.1	hypothetical protein	-
IUJ40_RS13275 (2585166)	2585166..2585780	-	615	WP_000191464.1	hypothetical protein	-
IUJ40_RS13280 (2585906)	2585906..2587111	+	1206	WP_140045523.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	2543604..2592602	48998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T181135 WP_001025401.1 NZ_CP064389:c2582437-2582192 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T181135 NZ_CP085806:344768-345076 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT181135 NZ_CP064389:2581858-2582223 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin