Detailed information of TA system TA181121

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 595699..595962
• Replicon: chromosome
• Accession: NZ_CP064389
• Organism: Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IUJ40_RS02955
• Protein ID: WP_001802298.1
• Coordinates: 595699..595803 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	595798..595962 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ40_RS02925	591083..591865	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
IUJ40_RS02930	591933..592790	+	858	WP_033841791.1	HAD family hydrolase	-
IUJ40_RS02940	593495..593587	-	93	WP_001790138.1	hypothetical protein	-
IUJ40_RS02945	593876..595012	+	1137	WP_000115564.1	SAP domain-containing protein	-
IUJ40_RS02950	595055..595538	+	484	Protein_580	recombinase family protein	-
IUJ40_RS02955	595699..595803	+	105	WP_001802298.1	hypothetical protein	Toxin
-	595798..595962	-	165	-	-	Antitoxin
IUJ40_RS02965	596237..597328	-	1092	WP_000495671.1	lytic regulatory protein	-
IUJ40_RS02970	597594..598574	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IUJ40_RS02975	598576..598896	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IUJ40_RS02980	599048..599713	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T181121 WP_001802298.1 NZ_CP064389:595699-595803 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T181121 NZ_CP085805:667943-668218 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT181121 NZ_CP064389:c595962-595798 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin