Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 330205..330722 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IUJ40_RS01570 Protein ID WP_000113262.1
Coordinates 330456..330722 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IUJ40_RS01565 Protein ID WP_000584499.1
Coordinates 330205..330456 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS01535 (325903) 325903..326622 + 720 WP_000479576.1 amino acid ABC transporter permease -
IUJ40_RS01540 (326619) 326619..327350 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IUJ40_RS01545 (327447) 327447..328697 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IUJ40_RS01550 (328952) 328952..329314 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IUJ40_RS01555 (329333) 329333..329932 + 600 WP_023487174.1 DsbA family protein -
IUJ40_RS01560 (329939) 329939..330040 + 102 WP_001791744.1 hypothetical protein -
IUJ40_RS01565 (330205) 330205..330456 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUJ40_RS01570 (330456) 330456..330722 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IUJ40_RS01575 (330757) 330757..330828 + 72 Protein_314 hypothetical protein -
IUJ40_RS01580 (331017) 331017..332567 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IUJ40_RS01585 (332753) 332753..333220 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IUJ40_RS01590 (333304) 333304..333486 + 183 WP_000230294.1 hypothetical protein -
IUJ40_RS01595 (333703) 333703..334527 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IUJ40_RS01600 (334760) 334760..335296 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T181120 WP_000113262.1 NZ_CP064389:330456-330722 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T181120 NZ_CP085805:619524-619892 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT181120 WP_000584499.1 NZ_CP064389:330205-330456 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT181120 NZ_CP085805:619306-619527 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References