Detailed information of TA system TA181118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 305185..305369
• Replicon: chromosome
• Accession: NZ_CP064389
• Organism: Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IUJ40_RS01435
• Protein ID: WP_000482650.1
• Coordinates: 305185..305292 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	305309..305369 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ40_RS01410	300547..301020	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IUJ40_RS01415	301143..302354	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IUJ40_RS01420	302536..303195	-	660	WP_000831298.1	membrane protein	-
IUJ40_RS01425	303255..304397	-	1143	WP_001176863.1	glycerate kinase	-
IUJ40_RS01430	304665..305051	+	387	WP_000779358.1	flippase GtxA	-
IUJ40_RS01435	305185..305292	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	305309..305369	-	61	-	-	Antitoxin
IUJ40_RS01440	305920..307683	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
IUJ40_RS01445	307708..309441	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IUJ40_RS01450	309672..309839	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T181118 WP_000482650.1 NZ_CP064389:305185-305292 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T181118 NZ_CP085805:119486-119797 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT181118 NZ_CP064389:c305369-305309 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin