Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 273346..273869 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IUJ40_RS01295 Protein ID WP_000074048.1
Coordinates 273603..273869 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IUJ40_RS01290 Protein ID WP_000587616.1
Coordinates 273346..273603 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS01265 (268425) 268425..269618 + 1194 WP_000675395.1 MFS transporter -
IUJ40_RS01270 (269842) 269842..270591 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
IUJ40_RS01275 (270787) 270787..272364 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IUJ40_RS01280 (272532) 272532..272987 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IUJ40_RS01285 (273046) 273046..273240 + 195 WP_001790145.1 hypothetical protein -
IUJ40_RS01290 (273346) 273346..273603 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUJ40_RS01295 (273603) 273603..273869 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IUJ40_RS01300 (274224) 274224..275300 + 1077 WP_001076671.1 M42 family metallopeptidase -
IUJ40_RS01305 (275548) 275548..276210 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IUJ40_RS01310 (276203) 276203..276979 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IUJ40_RS01315 (277375) 277375..278562 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T181117 WP_000074048.1 NZ_CP064389:273603-273869 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T181117 NZ_CP085805:c118253-117942 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT181117 WP_000587616.1 NZ_CP064389:273346-273603 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT181117 NZ_CP085805:c117941-117651 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References