Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3308196..3308977 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag IUJ38_RS16075 Protein ID WP_000626099.1
Coordinates 3308486..3308977 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag IUJ38_RS16070 Protein ID WP_001110452.1
Coordinates 3308196..3308489 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS16035 (3303808) 3303808..3304713 + 906 WP_001268200.1 YjiK family protein -
IUJ38_RS16040 (3305052) 3305052..3305510 + 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
IUJ38_RS16045 (3305719) 3305719..3305988 - 270 WP_010989096.1 hypothetical protein -
IUJ38_RS16050 (3305996) 3305996..3306211 - 216 WP_001595136.1 hypothetical protein -
IUJ38_RS16055 (3306234) 3306234..3306521 - 288 WP_001269916.1 transcriptional regulator RtsB -
IUJ38_RS16060 (3306518) 3306518..3307393 - 876 WP_000921675.1 AraC family transcriptional regulator -
IUJ38_RS16065 (3307658) 3307658..3307879 - 222 WP_001576552.1 hypothetical protein -
IUJ38_RS16070 (3308196) 3308196..3308489 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
IUJ38_RS16075 (3308486) 3308486..3308977 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
IUJ38_RS16080 (3309225) 3309225..3309977 - 753 WP_000842434.1 non-specific acid phosphatase -
IUJ38_RS16085 (3310080) 3310080..3310154 - 75 Protein_3138 porin family protein -
IUJ38_RS16090 (3311186) 3311186..3311563 - 378 WP_000916345.1 EthD family reductase -
IUJ38_RS16095 (3311635) 3311635..3311967 + 333 WP_001165471.1 MerR family transcriptional regulator -
IUJ38_RS16100 (3312058) 3312058..3312135 + 78 Protein_3141 helix-turn-helix domain-containing protein -
IUJ38_RS16110 (3312406) 3312406..3312981 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3305052..3305510 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T181079 WP_000626099.1 NZ_CP064385:3308486-3308977 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T181079 NZ_CP085802:c3747772-3747281 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT181079 WP_001110452.1 NZ_CP064385:3308196-3308489 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT181079 NZ_CP085802:c3748062-3747769 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References