Detailed information of TA system TA181078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2987270..2987872
• Replicon: chromosome
• Accession: NZ_CP064385
• Organism: Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: IUJ38_RS14650
• Protein ID: WP_001159630.1
• Coordinates: 2987270..2987581 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IUJ38_RS14655
• Protein ID: WP_000362050.1
• Coordinates: 2987582..2987872 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ38_RS14615 (2982383)	2982383..2982982	+	600	WP_000965695.1	glucose-1-phosphatase	-
IUJ38_RS14620 (2982976)	2982976..2983848	+	873	WP_000921427.1	virulence factor BrkB family protein	-
IUJ38_RS14625 (2983845)	2983845..2984282	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
IUJ38_RS14630 (2984327)	2984327..2985268	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IUJ38_RS14635 (2985283)	2985283..2985729	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
IUJ38_RS14640 (2985726)	2985726..2986037	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
IUJ38_RS14645 (2986123)	2986123..2987052	-	930	WP_001127703.1	alpha/beta hydrolase	-
IUJ38_RS14650 (2987270)	2987270..2987581	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
IUJ38_RS14655 (2987582)	2987582..2987872	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
IUJ38_RS14660 (2987919)	2987919..2988848	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IUJ38_RS14665 (2988845)	2988845..2989480	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IUJ38_RS14670 (2989477)	2989477..2990379	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T181078 WP_001159630.1 NZ_CP064385:2987270-2987581 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T181078 NZ_CP085802:c3640669-3640385 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT181078 WP_000362050.1 NZ_CP064385:2987582-2987872 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT181078 NZ_CP085802:c3640901-3640659 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64