181074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2425325..2425863 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag IUJ38_RS12025 Protein ID WP_001526148.1
Coordinates 2425325..2425600 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag IUJ38_RS12030 Protein ID WP_000729713.1
Coordinates 2425603..2425863 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS12020 (2422532) 2422532..2425237 + 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -
IUJ38_RS12025 (2425325) 2425325..2425600 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
IUJ38_RS12030 (2425603) 2425603..2425863 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IUJ38_RS12035 (2425972) 2425972..2426991 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
IUJ38_RS12040 (2426995) 2426995..2428209 - 1215 WP_001105522.1 RNA-splicing ligase RtcB -
IUJ38_RS12045 (2428557) 2428557..2428748 - 192 Protein_2361 TROVE domain-containing protein -
IUJ38_RS12050 (2428757) 2428757..2430310 - 1554 WP_000013008.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T181074 WP_001526148.1 NZ_CP064385:c2425600-2425325 [Salmonella enterica subsp. enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T181074 NZ_CP085802:2979874-2980092 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT181074 WP_000729713.1 NZ_CP064385:c2425863-2425603 [Salmonella enterica subsp. enterica]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT181074 NZ_CP085802:2979472-2979846 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References