Detailed information of TA system TA181054

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4129054..4129275
• Replicon: chromosome
• Accession: NZ_CP064383
• Organism: Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: IUJ36_RS21080
• Protein ID: WP_001295224.1
• Coordinates: 4129054..4129161 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4129210..4129275 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ36_RS21055 (4124307)	4124307..4125059	-	753	Protein_4132	cellulose biosynthesis protein BcsQ	-
IUJ36_RS21060 (4125071)	4125071..4125259	-	189	WP_001063316.1	cellulose biosynthesis protein BcsR	-
IUJ36_RS21065 (4125532)	4125532..4127103	+	1572	WP_001204920.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
IUJ36_RS21070 (4127100)	4127100..4127291	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
IUJ36_RS21075 (4127288)	4127288..4128967	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
IUJ36_RS21080 (4129054)	4129054..4129161	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
- (4129210)	4129210..4129275	+	66	NuclAT_17	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_17	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_17	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_17	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_22	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_22	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_22	-	Antitoxin
- (4129210)	4129210..4129275	+	66	NuclAT_22	-	Antitoxin
IUJ36_RS21085 (4129637)	4129637..4130908	+	1272	WP_001301684.1	aromatic amino acid transport family protein	-
IUJ36_RS21090 (4130938)	4130938..4131942	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
IUJ36_RS21095 (4131939)	4131939..4132922	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
IUJ36_RS21100 (4132933)	4132933..4133835	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T181054 WP_001295224.1 NZ_CP064383:c4129161-4129054 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T181054 NZ_CP085801:370418-370816 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT181054 NZ_CP064383:4129210-4129275 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin