Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1942679..1943150 Replicon chromosome
Accession NZ_CP064383
Organism Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag IUJ36_RS10195 Protein ID WP_001303511.1
Coordinates 1942872..1943150 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag IUJ36_RS10190 Protein ID WP_001302048.1
Coordinates 1942679..1942870 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ36_RS10150 (1937886) 1937886..1938470 - 585 WP_000206793.1 DUF551 domain-containing protein -
IUJ36_RS10155 (1938527) 1938527..1938922 - 396 WP_001118159.1 DUF977 family protein -
IUJ36_RS10160 (1938938) 1938938..1939707 - 770 Protein_1993 DUF1627 domain-containing protein -
IUJ36_RS10165 (1939733) 1939733..1940473 - 741 WP_000788938.1 ATP-binding protein -
IUJ36_RS10170 (1940480) 1940480..1941442 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
IUJ36_RS10175 (1941465) 1941465..1941890 - 426 WP_000693943.1 toxin YdaT family protein -
IUJ36_RS10180 (1941887) 1941887..1942189 - 303 WP_000172738.1 transcriptional regulator -
IUJ36_RS10185 (1942287) 1942287..1942658 + 372 WP_001169686.1 hypothetical protein -
IUJ36_RS10190 (1942679) 1942679..1942870 + 192 WP_001302048.1 hypothetical protein Antitoxin
IUJ36_RS10195 (1942872) 1942872..1943150 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ36_RS10200 (1943503) 1943503..1943802 + 300 WP_001240334.1 hypothetical protein -
IUJ36_RS10205 (1943874) 1943874..1944092 + 219 WP_001171930.1 protein YdfC -
IUJ36_RS10210 (1944661) 1944661..1944849 + 189 WP_000449192.1 cell division inhibition protein DicB -
IUJ36_RS10215 (1944846) 1944846..1945037 + 192 WP_001090200.1 DUF1482 family protein -
IUJ36_RS10220 (1945130) 1945130..1947601 + 2472 WP_000048458.1 exonuclease -
IUJ36_RS10225 (1947674) 1947674..1947925 + 252 WP_000005552.1 excisionase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleA/espI 1901448..1950311 48863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T181038 WP_001303511.1 NZ_CP064383:1942872-1943150 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T181038 NZ_CP085800:c1527919-1527816 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT181038 WP_001302048.1 NZ_CP064383:1942679-1942870 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT181038 NZ_CP085800:1527814-1527959 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References