Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 3333780..3335023 | Replicon | chromosome |
| Accession | NZ_CP064378 | ||
| Organism | Legionella pneumophila subsp. pneumophila strain PartS-Lpneumophila-RM8376 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | Q5ZSZ6 |
| Locus tag | IUJ54_RS14865 | Protein ID | WP_010948074.1 |
| Coordinates | 3333780..3334718 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | Q5ZSZ7 |
| Locus tag | IUJ54_RS14870 | Protein ID | WP_010948073.1 |
| Coordinates | 3334715..3335023 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ54_RS15260 | 3328943..3329074 | + | 132 | WP_015444112.1 | hypothetical protein | - |
| IUJ54_RS14840 (IUJ54_14805) | 3329250..3329915 | + | 666 | WP_015444114.1 | hypothetical protein | - |
| IUJ54_RS14845 | 3329896..3330186 | + | 291 | WP_223804318.1 | hypothetical protein | - |
| IUJ54_RS14850 (IUJ54_14815) | 3330656..3331924 | - | 1269 | WP_010948076.1 | lpg2372 family Dot/Icm T4SS effector | - |
| IUJ54_RS14855 (IUJ54_14820) | 3332261..3332467 | + | 207 | WP_015444115.1 | hypothetical protein | - |
| IUJ54_RS14860 (IUJ54_14825) | 3332623..3333237 | - | 615 | WP_010948075.1 | hypothetical protein | - |
| IUJ54_RS14865 (IUJ54_14830) | 3333780..3334718 | - | 939 | WP_010948074.1 | lpg2370 family Dot/Icm T4SS effector | Toxin |
| IUJ54_RS14870 (IUJ54_14835) | 3334715..3335023 | - | 309 | WP_010948073.1 | HipA N-terminal domain-containing protein | Antitoxin |
| IUJ54_RS14875 (IUJ54_14840) | 3335020..3335247 | - | 228 | WP_006870829.1 | helix-turn-helix transcriptional regulator | - |
| IUJ54_RS14880 (IUJ54_14845) | 3336080..3336355 | + | 276 | WP_010948072.1 | helix-turn-helix domain-containing protein | - |
| IUJ54_RS14885 (IUJ54_14850) | 3336421..3338172 | + | 1752 | WP_010948071.1 | DUF927 domain-containing protein | - |
| IUJ54_RS14890 (IUJ54_14855) | 3338175..3338315 | + | 141 | WP_153802426.1 | hypothetical protein | - |
| IUJ54_RS14895 (IUJ54_14860) | 3338500..3338865 | + | 366 | WP_010948070.1 | TraK family protein | - |
| IUJ54_RS14900 (IUJ54_14865) | 3339222..3339587 | - | 366 | WP_010948069.1 | BRCT domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3339826..3341001 | 1175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 36077.81 Da Isoelectric Point: 8.6882
>T181032 WP_010948074.1 NZ_CP064378:c3334718-3333780 [Legionella pneumophila subsp. pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD
Download Length: 939 bp
>T181032 NZ_CP085799:3857150-3857518 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11557.38 Da Isoelectric Point: 4.5994
>AT181032 WP_010948073.1 NZ_CP064378:c3335023-3334715 [Legionella pneumophila subsp. pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR
Download Length: 309 bp
>AT181032 NZ_CP085799:3856932-3857153 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|