181008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 40741..41468 Replicon chromosome
Accession NZ_CP064376
Organism Shigella sonnei strain PartP-Ssonnei-RM8376

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag IUJ51_RS00240 Protein ID WP_000547563.1
Coordinates 40741..41052 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IUJ51_RS00245 Protein ID WP_000126296.1
Coordinates 41049..41468 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ51_RS00210 (35895) 35895..37592 + 1698 WP_001288143.1 formate hydrogenlyase subunit HycE -
IUJ51_RS00215 (37602) 37602..38144 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
IUJ51_RS00220 (38144) 38144..38911 + 768 WP_000067403.1 formate hydrogenlyase subunit HycG -
IUJ51_RS00225 (38908) 38908..39318 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
IUJ51_RS00230 (39311) 39311..39781 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
IUJ51_RS00235 (39806) 39806..40579 + 774 WP_001026444.1 hypothetical protein -
IUJ51_RS00240 (40741) 40741..41052 + 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
IUJ51_RS00245 (41049) 41049..41468 + 420 WP_000126296.1 helix-turn-helix domain-containing protein Antitoxin
IUJ51_RS00250 (41582) 41582..43006 - 1425 WP_000110319.1 6-phospho-beta-glucosidase AscB -
IUJ51_RS00255 (43015) 43015..44472 - 1458 WP_001107890.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
IUJ51_RS00260 (44732) 44732..45742 + 1011 WP_001402444.1 DNA-binding transcriptional regulator AscG -
IUJ51_RS00265 (45890) 45890..46417 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T181008 WP_000547563.1 NZ_CP064376:40741-41052 [Shigella sonnei]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T181008 NZ_CP085798:c2012005-2011850 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.38 Da        Isoelectric Point: 4.3653

>AT181008 WP_000126296.1 NZ_CP064376:41049-41468 [Shigella sonnei]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNQEFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT181008 NZ_CP085798:2012017-2012075 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References