Detailed information of TA system TA180998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 695441..695778
• Replicon: chromosome
• Accession: NZ_CP064374
• Organism: Enterococcus faecalis strain PartL-Efaecalis-RM8376

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: IUJ47_RS03395
• Protein ID: WP_002381035.1
• Coordinates: 695441..695584 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	695516..695778 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ47_RS03375	691533..692171	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
IUJ47_RS03380	692857..694473	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
IUJ47_RS03385	694802..694951	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
IUJ47_RS03390	695070..695210	+	141	WP_073340360.1	putative holin-like toxin	-
IUJ47_RS03395	695441..695584	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	695516..695778	-	263	-	-	Antitoxin
IUJ47_RS03400	695779..699606	-	3828	WP_010816211.1	WxL domain-containing protein	-
IUJ47_RS03405	699593..699955	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T180998 WP_002381035.1 NZ_CP064374:695441-695584 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T180998 NZ_CP085797:1885052-1885465 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT180998 NZ_CP064374:c695778-695516 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin