180995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 695143..695584 Replicon chromosome
Accession NZ_CP064374
Organism Enterococcus faecalis strain PartL-Efaecalis-RM8376

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag IUJ47_RS03395 Protein ID WP_002381035.1
Coordinates 695441..695584 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 695143..695344 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ47_RS03370 690277..691269 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
IUJ47_RS03375 691533..692171 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
IUJ47_RS03380 692857..694473 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -
IUJ47_RS03385 694802..694951 + 150 WP_002411240.1 type I toxin-antitoxin system toxin PepG1 -
IUJ47_RS03390 695070..695210 + 141 WP_073340360.1 putative holin-like toxin -
- 695143..695344 - 202 - - Antitoxin
IUJ47_RS03395 695441..695584 + 144 WP_002381035.1 putative holin-like toxin Toxin
IUJ47_RS03400 695779..699606 - 3828 WP_010816211.1 WxL domain-containing protein -
IUJ47_RS03405 699593..699955 - 363 WP_002378868.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-47)


Sequences


Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T180995 WP_002381035.1 NZ_CP064374:695441-695584 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T180995 NZ_CP085797:1260231-1260716 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 202 bp

>AT180995 NZ_CP064374:c695344-695143 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2


Antitoxin

Download structure file

References