Detailed information of TA system TA180992

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 695070..695344
• Replicon: chromosome
• Accession: NZ_CP064374
• Organism: Enterococcus faecalis strain PartL-Efaecalis-RM8376

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: IUJ47_RS03390
• Protein ID: WP_073340360.1
• Coordinates: 695070..695210 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	695143..695344 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ47_RS03370	690277..691269	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
IUJ47_RS03375	691533..692171	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
IUJ47_RS03380	692857..694473	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
IUJ47_RS03385	694802..694951	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
IUJ47_RS03390	695070..695210	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	695143..695344	-	202	-	-	Antitoxin
IUJ47_RS03395	695441..695584	+	144	WP_002381035.1	putative holin-like toxin	-
IUJ47_RS03400	695779..699606	-	3828	WP_010816211.1	WxL domain-containing protein	-
IUJ47_RS03405	699593..699955	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T180992 WP_073340360.1 NZ_CP064374:695070-695210 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T180992 NZ_CP085797:c559789-559298 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT180992 NZ_CP064374:c695344-695143 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin